TISSUE-SPECIFIC AND DEVELOPMENTALLY REGULATED TRANSCRIPTION OF THE INSULIN-LIKE GROWTH FACTOR-II GENE
TISSUE-SPECIFIC AND DEVELOPMENTALLY REGULATED TRANSCRIPTION OF THE INSULIN-LIKE GROWTH FACTOR-II GENE
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DOI：
10.1089/dna.1987.6.283
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发表时间：
1987-08-01
期刊：
影响因子：
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通讯作者：
ULLRICH, A
中科院分区：
文献类型：
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作者：
GRAY, A;TAM, AW;ULLRICH, A
大鼠和人类IGF-2基因位点的转录异常复杂。这些基因的表达模式在组织之间和在发育的不同阶段的给定组织内都不同。选择性剪接或可能的转录起始事件产生含有不同5′-非翻译前导序列的变体IGF-2 mRNA。这些前导外显子序列与非IGF-2 mRNA共享。某些非编码IGF-2基因序列元件被广泛转录，并在人类基因组的其他地方发现多个拷贝。此外，IGF-2 mRNA水平在多种人类恶性肿瘤中特别高。
Transcription of the rat and human IGF-2 gene loci is unusually complex. The pattern of expression of these genes varies both between tissues and within a given tissue during different stages of development. Alternative splicing or possibly transcriptional initiation events generate variant IGF-2 mRNAs that contain different 5′-untranslated leader sequences. These leader exon sequences are shared with non-IGF-2 mRNAs. Certain noncoding IGF-2 gene sequence elements are transcribed extensively and are found in multiple copies elsewhere in the human genome. Furthermore, IGF-2 mRNA levels are particularly high in a variety of human malignancies.