Gold nanoparticles decorated by amphiphilic block copolymer as efficient system for drug delivery.
Gold nanoparticles decorated by amphiphilic block copolymer as efficient system for drug delivery.
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由两亲性嵌段共聚物修饰的金纳米粒子作为有效的药物输送系统。
DOI：
10.1166/jbn.2013.1470
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发表时间：
2013
影响因子：
2.9
通讯作者：
Min‐Hui Li
中科院分区：
文献类型：
--
作者：
Zhifei Wang;Lin Jia;Min‐Hui Li
研制了一种基于巯基功能化两亲二嵌段共聚物稳定的金纳米粒子（Au NPs）给药系统。采用可逆加成-断裂转移（RAFT）聚合法制备了聚乙二醇-b-聚丙烯酸正丁酯（MPEG-b-PBA）共聚物，并将疏水嵌段PBA末端的硫代羰基硫基进一步还原为巯基。作为疏水药物的模型分子，芘通过物理包载在Au NPs周围的壳层疏水内部。紫外可见分光光度分析表明，与小分子配体修饰的金纳米粒子相比，所制备的金纳米粒子-芘纳米复合物在水溶液中具有良好的稳定性和较高的载药量。此外，它们的装载能力和释放行为都与疏水块的链长密切相关。总之，我们在这里报告了一种通用和简单的方法来制备金NP-聚合物杂化物，该杂化物适用于通过RAFT聚合合成的各种两亲共聚物，并可用于生产高效的金NP基药物载体。
A drug delivery system based on gold nanoparticles (Au NPs) stabilized by an thiol-functionalized amphiphilic diblock copolymer was developed. The copolymer, poly(ethylene glycol)-b-poly(n-butyl acrylate) (MPEG-b-PBA), was synthesized by Reversible Addition-Fragmentation Transfer (RAFT) polymerization and the thiocarbonylthio group at the end of the hydrophobic block PBA was further reduced to thiol group. Pyrene, used as a model molecule for the hydrophobic drugs, was loaded in the hydrophobic interior of the shell around Au NPs by physical entrapment. The analysis performed by UV-Vis spectrophotometer show that the obtained Au NPs-pyrene nanocomposites have good stability in the aqueous solution and high drug loading capacity in comparison with Au NPs decorated with small molecular ligands. In addition, both their loading capacity and release behavior were found closely related to the chain length of hydrophobic block. In conclusion, we report here a versatile and simple procedure to fabricate Au NP-polymer hybrids that is applicable to various amphiphilic copolymers synthesized by RAFT polymerization and useful to produce efficient Au NP based drug carriers.