Left ventricular changes resulting from chronic aortic regurgitation in dogs.
Left ventricular changes resulting from chronic aortic regurgitation in dogs.
复制标题
狗慢性主动脉瓣关闭不全导致左心室变化。
DOI：
10.1016/s0002-9149(84)80227-1
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
C. Pepine
中科院分区：
文献类型：
--
作者：
R. Feldman;W. Nichols;L. Thompson;D. Paley;R. Goldman;C. Conti;C. Pepine
对7只闭胸犬进行主动脉瓣穿孔置管诱导慢性主动脉反流（AR）。在这些幼犬体内产生AR大约2年后，它们的生长情况与对照组相似。随着左室舒张末期容积（平均116%）和质量（平均114%）的增加，与对照组相比，AR动物左室（LV）扩张和肥厚逐渐加重。所描述的诱导AR的技术不会干扰动物的正常生长发育，并且允许研究由此产生的左室扩张和肥厚的功能特征，而不会增加开胸和心包切开术的影响。
Chronic aortic regurgitation (AR) was induced by aortic valve perforation using catheterization techniques in 7 closed-chest puppies. Approximately 2 years after the creation of AR in these puppies, their growth was similar to that in littermate controls. A gradually progressive degree of left ventricular (LV) dilation and hypertrophy occurred as LV end-diastolic volume (average 116%) and mass (average 114%) increased in animals with AR compared with that in the littermate controls. The technique described to induce AR did not interfere with the normal growth and development of the animals, and permitted study of the functional characteristics of the resulting LV dilation and hypertrophy without added effects of thoracotomy and pericardiotomy.