Antiphospholipid antibodies in patients with lupus nephritis
Antiphospholipid antibodies in patients with lupus nephritis
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DOI：
10.1081/jdi-120024290
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发表时间：
2003-01-01
期刊：
影响因子：
3
通讯作者：
Certíková, V
中科院分区：
文献类型：
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作者：
Fialová, L;Zima, T;Certíková, V
本研究的目的是比较狼疮性肾炎患者中抗心磷脂抗体与其他类型的抗磷脂抗体（抗磷脂酰丝氨酸- aps、抗磷脂酰肌醇- api、抗磷脂酰乙醇胺- ape）的患病率，并发现各种aPL的检查是否对患者的进一步诊断有价值。此外，我们还测定了抗β(2)-糖蛋白I （β (2)GPI）和氧化低密度脂蛋白（抗oxLDL）的自身抗体水平，并研究了抗β (2)GPI和oxLDL抗体之间的关系，并通过ELISA方法进行了评估。对22例狼疮性肾炎患者进行了研究。对照组由62名健康的献血者组成。与对照组相比，狼疮性肾炎患者的所有apl发生率均有统计学意义。在SLE患者中，与至少两种不同磷脂反应的多特异性抗体的患病率为82%。SLE患者血清中IgG - anti-beta(2)GPI水平显著升高（p = 0.0003）。患者组血清中抗氧化低密度脂蛋白水平与对照组无显著差异。部分抗β (2)GPI阳性，aCL或抗oxldl阴性，反之亦然。由此可见，狼疮肾炎患者血清中抗- β (2)GPI和抗oxldl等aPL的产生高于健康献血者。我们认为，各种类型aPL的估计可能对肾脏疾病患者群体的选择很重要。aPL的合成可以反映血管壁上修饰的几种抗原的自身免疫反应的扩散。
The aim of this study was to compare the prevalence of anticardiolipin antibodies with other types of antiphospholipid antibodies (aPL) (antiphosphatidylserine-aPS, antiphosphatidylinositol-aPI, antiphosphatidylethanolamine-aPE) in patients with lupus nephritis and to find if the examination of a panel of various aPL is valuable for further diagnosis of patients. Additionally we determined the levels of autoantibodies against beta(2)-glycoprotein I (beta(2)GPI) and oxidized low-density lipoprotein (anti-oxLDL) and also investigated the relationship between antibodies against beta(2)GPI and oxLDL, which were assessed by ELISA methods. Twenty-two patients with lupus nephritis were studied. The control group consisted of 62 healthy blood donors. A statistically significant higher occurrence of all aPLs in the patients with lupus nephritis in comparison to the control group was found. The prevalence of polyspecific antibodies, which reacted with at least two various phospholipids, was 82% in the group of SLE patients. Significantly higher levels of IgG anti-beta(2)GPI in the sera of SLE patients (p = 0.0003) was detected. The levels of anti-oxLDL in the sera of the patients group did not differ significantly from the control one. Some positive samples for anti-beta(2)GPI and negative for aCL or anti-oxLDL and vice versa were found. It can be concluded that the production of aPL including anti-beta(2)GPI and anti-oxLDL in the lupus nephritis patients is higher in comparison with healthy blood donors. We assume that the estimation of various types of aPL may be important in the selection of the group patients with renal diseases. The synthesis or aPL can reflect the spreading of the autoimmune response for several antigens modified on the vessel wall.