GerES IV: Phthalate metabolites and bisphenol A in urine of German children
GerES IV: Phthalate metabolites and bisphenol A in urine of German children
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DOI：
10.1016/j.ijheh.2009.08.002
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发表时间：
2009-11-01
影响因子：
6
通讯作者：
Kolossa-Gehring, Marike
中科院分区：
文献类型：
--
作者：
Becker, Kerstin;Goeen, Thomas;Kolossa-Gehring, Marike
对GerES IV的尿样进行了DEHP（MEHP 5 OH-MEHP、5 oxo-MEHP、5cx-MEPP和2cx-MMHP）、DnBP和DiBP（MnBP和MiBP）、BBzP（MBzP）、DiNP（7 OH-MMeOP、7 oxo-MMeOP和7 cx-MMeHP）和双酚A（BPA）代谢物浓度分析，以评估德国儿童的代表性暴露。从德国3 ~ 14岁儿童的1800份GerES IV晨尿中随机抽取600份，几乎所有的晨尿（N = 599）均能检出所有代谢产物。描述性数据分析得出5-OH-MEHP和5-oxo-MEHP的平均浓度分别为48 μ g/l和37 μ g/l。7 OH-MMeCP的平均浓度为11 μ g/l。MnBP、MiNP、MBzP的平均水平分别为96 μ g/l、94 μ g/l和18 μ g/l。邻苯二甲酸酯代谢物的浓度随着年龄的增加而降低。与德国成年人相比，所有儿童的尿液浓度都比同一个十年中分析的成年人高出三到五倍。对于一些儿童，尿液中5 OH-MEHP和5 oxo-MEHP的总和水平高于德国人体生物监测值（HBM I）500 μ g/l，这表明不能充分肯定地排除这些受试者的不良健康影响。尿液中BPA的平均浓度为2.7微克/升根据尿液中测得的浓度粗略计算每日摄入量，得出的每日摄入量比现行EFSA参考剂量50 μ g/kg bw/d低两个数量级。(C)2009年Elsevier GmbH。All rights reserved.
Urine samples from GerES IV were analysed for concentrations of the metabolites of DEHP (MEHP 5OH-MEHP, 5oxo-MEHP, 5cx-MEPP, and 2cx-MMHP), DnBP and DiBP (MnBP and MiBP), BBzP (MBzP), DiNP (7OH-MMeOP, 7oxo-MMeOP and 7cx-MMeHP), and bisphenol A (BPA) to assess the exposure of German children on a representative basis. 600 morning urine samples had been randomly chosen from stored 1800 GerES IV samples originating from 3 to 14 year old children living in Germany.All metabolites could be detected in nearly all urine samples (N = 599). Descriptive data analysis leads to mean concentrations of 5-OH-MEHP and 5-oxo-MEHP of 48 mu g/l and 37 mu g/l, respectively. The mean concentration of 7OH-MMeCP was 11 mu g/l. MnBP, MiNP, MBzP showed mean levels of 96 mu g/l, 94 mu g/l, and 18 mu g/l, respectively. The concentrations of the phthalate metabolites decreased with increasing age. Compared to German adults all children showed three to five fold higher urine concentrations than adults analysed in the same decade.For some children the levels of the sum of 5OH-MEHP and 5oxo-MEHP in urine were higher than the German human biomonitoring value (HBM I) of 500 mu g/l, which indicates that adverse health effects cannot be excluded for these subjects with Sufficient certainty.The mean concentration of BPA in urine was 2.7 mu g/l. A rough calculation of the daily intakes on the basis of the measured concentrations in urine resulted in daily intakes two orders of magnitude lower than the Current EFSA reference dose of 50 mu g/kg bw/d. (C) 2009 Elsevier GmbH. All rights reserved.