Cholinergic modulation of working memory activity in primate prefrontal cortex.
Cholinergic modulation of working memory activity in primate prefrontal cortex.
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灵长类动物前额皮质工作记忆活动的胆碱能调节。
DOI：
10.1152/jn.00148.2011
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发表时间：
2011
影响因子：
2.5
通讯作者：
Constantinidis,Christos
中科院分区：
文献类型：
--
作者：
Zhou,Xin;Qi,Xue-Lian;Douglas,Kristy;Palaninathan,Kathini;Kang,HyunSug;Buccafusco,JerryJ;Blake,DavidT;Constantinidis,Christos
The prefrontal cortex, a cortical area essential for working memory and higher cognitive functions, is modulated by a number of neurotransmitter systems, including acetylcholine; however, the impact of cholinergic transmission on prefrontal activity is not well understood. We relied on systemic administration of a muscarinic receptor antagonist, scopolamine, to investigate the role of acetylcholine on primate prefrontal neuronal activity during execution of working memory tasks and recorded neuronal activity with chronic electrode arrays and single electrodes. Our results indicated a dose-dependent decrease in behavioral performance after scopolamine administration in all the working memory tasks we tested. The effect could not be accounted for by deficits in visual processing, eye movement responses, or attention, because the animals performed a visually guided saccade task virtually error free, and errors to distracting stimuli were not increased. Performance degradation under scopolamine was accompanied by decreased firing rate of the same cortical sites during the delay period of the task and decreased selectivity for the spatial location of the stimuli. These results demonstrate that muscarinic blockade impairs performance in working memory tasks and prefrontal activity mediating working memory.
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影响因子：
3.1
作者：
Buccafusco, JJ;Terry, AV
通讯作者：
Terry, AV
影响因子：
3.4
作者：
Buccafusco, Jerry J.;Terry, Alvin V., Jr.;Warner, Samantha E.
通讯作者：
Warner, Samantha E.
影响因子：
9.9
作者：
Rogers, SL;Farlow, MR;Walshe, TM
通讯作者：
Walshe, TM
DOI：
--
发表时间：
1992-02
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
C. Bolden;B. Cusack;Elliott Richelson
通讯作者：
C. Bolden;B. Cusack;Elliott Richelson
灵长类动物基底核功能的电生理学研究。
影响因子：
--
作者：
R. Richardson;M. DeLong
通讯作者：
M. DeLong