Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer.
Fiberoptic bronchoscopic laser photoradiation for tumor localization in lung cancer.
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纤维支气管镜激光光照射用于肺癌肿瘤定位。
DOI：
10.1378/chest.82.1.10
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发表时间：
1982
期刊：
影响因子：
9.6
通讯作者：
Nishimiya Katsuaki
中科院分区：
文献类型：
--
作者：
Hayata Yoshihiro;Kato Harubumi;Konaka Chimori;Ono Jutaro;Matsushima Yasushi;Kazuo Yoneyama;Nishimiya Katsuaki
血卟啉衍生物 (HpD) 给药和激光光照射相结合，阐明了该系统在定位肺癌肿瘤方面的临床适用性。它被用于治疗 16 例肺癌和 1 例严重非典型鳞状化生病例。静脉注射2.0至4.0mg/kg HpD后48小时照射肿瘤并观察荧光。 13例鳞状上皮化生肺癌病例中观察到荧光，但其中3例肺癌病例结果呈阴性。阳性病例中有 1 例隐匿性癌症，2 例侵犯气管，常规纤维支气管镜难以识别，严重非典型鳞状化生也是如此。在三个不发出荧光的肺癌病例中，肿瘤被血液、坏死组织或正常粘膜遮盖。该方法有望用于恶性肿瘤的诊断。然而，需要进一步完善和更多研究来阐明恶性组织和严重非典型非恶性组织之间的明确区别。
Hematoporphyrin derivative (HpD) administration and laser photoradiation were combined to clarify the system's clinical applicability in localizing lung cancer tumors. It was used in 16 cases of lung cancer and in one case of severely atypical squamous metaplasia. Tumors were irradiated 48 hours after intravenous injection of 2.0 to 4.0 mg/kg HpD and fluorescence observed. Fluorescence was seen in 13 lung cancer cases in the case of squamous metaplasia, but results were negative in three of the cases of lung cancer. Among the positive cases was one of occult cancer and two invading the trachea, difficult to recognize by conventional fiberoptic bronchoscopy, as was the severely atypical squamous metaplasia. In the three lung cancer cases not fluorescing, the tumors were obscured by blood, necrotic tissue, or normal mucosa. The method holds promise in the diagnosis of malignant tumors. Nevertheless, it needs further refinement and more studies to elucidate definitive differentiation between malignant and severely atypical, nonmalignant tissue.