Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland
Biokinetic analysis of tissue boron (10B) concentrations of glioma patients treated with BNCT in Finland
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DOI：
10.1016/j.apradiso.2015.08.014
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发表时间：
2015-12-01
影响因子：
1.6
通讯作者：
Joensuu, H.
中科院分区：
文献类型：
--
作者：
Koivunoro, H.;Hippelainen, E.;Joensuu, H.
1999年至2011年，芬兰共有98名胶质瘤患者接受了硼苯丙氨酸 - 氟（BPA - F）介导的硼中子俘获疗法（BNCT）。其中39人（40%）因新诊断的胶质母细胞瘤接受了手术，59人（60%）在手术后出现恶性胶质瘤复发。在本研究中，我们基于动态氟 - 18 - 硼苯丙氨酸正电子发射断层扫描（F - 18 - BPA - PET）研究应用了一个封闭的三室模型，以估计肿瘤和正常脑组织中硼苯丙氨酸 - 氟浓度随时间的变化。共有22名复发性胶质瘤患者在一项临床试验中接受了治疗，我们以其各自测量的全血硼 - 10浓度作为模型的输入进行了评估。根据中子照射期间组织中建模的硼 - 10浓度，重新计算了肿瘤和正常脑组织所接受的辐射剂量。该模型预测，与先前估计的剂量相比，平均肿瘤剂量变化在 - 7%到 + 29%之间（平均 + 11%），并且由于肿瘤与血液浓度比并非恒定，以及中子照射时大脑中估计的硼 - 10浓度相当高，平均正常脑组织剂量比先前估计的高17%到61%（平均36%）。（C）2015爱思唯尔有限公司。保留所有权利。
A total of 98 patients with glioma were treated with BPA-F-mediated boron neutron capture therapy (BNCT) in Finland from 1999 to 2011. Thirty-nine (40%) had undergone surgery for newly diagnosed glioblastoma and 59 (60%) had malignant glioma recurrence after surgery. In this study we applied a closed 3-compartment model based on dynamic F-18-BPA-PET studies to estimate the BPA-F concentrations in the tumor and the normal brain with time. Altogether 22 patients with recurrent glioma, treated within the context of a clinical trial, were evaluated using their individual measured whole blood 1013 concentrations as an input to the model. The delivered radiation doses to tumor and the normal brain were recalculated based on the modeled B-10 concentrations in the tissues during neutron irradiation. The model predicts from -7% to +29% (average, + 11%) change in the average tumor doses as compared with the previously estimated doses, and from 17% to 61% (average, 36%) higher average normal brain doses than previously estimated due to the non-constant tumor-to-blood concentration ratios and considerably higher estimated 1013 concentrations in the brain at the time of neutron irradiation. (C) 2015 Elsevier Ltd. All rights reserved.