How do red blood cells know when to die?
How do red blood cells know when to die?
复制标题
DOI：
10.1098/rsos.160850
复制
发表时间：
2017-04
影响因子：
3.5
通讯作者：
Arias CF
中科院分区：
文献类型：
--
作者：
Arias CF;Arias CF
人红细胞（RBC）通常在120日龄时被脾窦和肝窦的巨噬细胞吞噬。红细胞的破坏最终由磷脂酰丝氨酸（PS）和CD 47对巨噬细胞吞噬活性的拮抗作用控制。在这项工作中，我们介绍了一个概念模型，解释红细胞寿命的结果，这些分子的动态。具体而言，我们认为PS和CD47定义了一种分子算法，该算法设定了RBC吞噬作用的时间。我们表明，在文献中描述的RBC寿命的显着变化可以解释为该算法的替代结果时，它是在不同的条件下执行的氧气供应。这里介绍的理论模型提供了一个统一的框架，以了解各种有关RBC生物学的经验观察。它还强调了RBC寿命作为RBC稳态的关键要素的作用。
Human red blood cells (RBCs) are normally phagocytized by macrophages of splenic and hepatic sinusoids at 120 days of age. The destruction of RBCs is ultimately controlled by antagonist effects of phosphatidylserine (PS) and CD47 on the phagocytic activity of macrophages. In this work, we introduce a conceptual model that explains RBC lifespan as a consequence of the dynamics of these molecules. Specifically, we suggest that PS and CD47 define a molecular algorithm that sets the timing of RBC phagocytosis. We show that significant changes in RBC lifespan described in the literature can be explained as alternative outcomes of this algorithm when it is executed in different conditions of oxygen availability. The theoretical model introduced here provides a unified framework to understand a variety of empirical observations regarding RBC biology. It also highlights the role of RBC lifespan as a key element of RBC homeostasis.