Expression and correlation analysis of Skp2 and CBX7 in cervical cancer
Expression and correlation analysis of Skp2 and CBX7 in cervical cancer
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Skp2和CBX7在宫颈癌中的表达及相关性分析
DOI：
10.1136/jclinpath-2021-207752
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发表时间：
2021-07-19
影响因子：
3.4
通讯作者：
Li, Rong
中科院分区：
文献类型：
--
作者：
Maimaitirexiati, Gulikezi;Tian, Ping;Li, Rong
S期激酶相关蛋白2（Skp2）癌蛋白在多种癌组织中过度表达，促进癌症恶性发展。染色体盒同源物7（CBX7）蛋白在不同类型的癌组织中表达水平存在差异，但其在宫颈癌中的作用尚不清楚。我们的目的是检查 Skp2 和 CBX7 蛋白的表达和临床意义以及它们在宫颈癌中的相关性。方法采用免疫组织化学法检测64例宫颈癌患者癌组织及癌旁组织中Skp2、CBX7蛋白的表达情况。收集这些患者的相关临床病理资料，进行相关性比较和分析。结果 Skp2蛋白在宫颈癌组织中的表达量（87.5%）高于癌旁组织（14.1%），且表达量与临床分期、恶性程度、淋巴转移、血管侵犯、间质侵犯呈正相关。 CBX7蛋白在宫颈癌中的表达量(48.4%)低于癌旁组织(96.8%),且表达量与临床分期、恶性程度、间质侵犯、血管侵犯及淋巴转移呈负相关。宫颈癌组织及癌旁组织中 Skp2 蛋白和 CBX7 蛋白的表达量呈负相关。 Skp2、CBX7蛋白的表达与宫颈癌的临床病理特征密切相关。结论 CBX7可能在宫颈癌中发挥抑癌基因的作用，为宫颈癌的诊断和新的靶向治疗提供参考价值。
Aims S-phase kinase-associated protein 2 (Skp2) oncoprotein is overexpressed in a variety of cancer tissues and promotes the malignant development of cancer. The expression levels of chromobox homolog 7 (CBX7) protein are varied among different types of cancer tissues, but its role in cervical cancer is not clear. We aimed to examine the expression and clinical significance of Skp2 and CBX7 proteins as well as their correlations in cervical cancer. Methods Immunohistochemistry was used to detect the expression of Skp2 and CBX7 proteins in the cancerous tissues and adjacent tissues of 64 patients with cervical cancer. Relevant clinicopathological data of these patients were collected, compared and analysed for the correlations. Results The expression of Skp2 protein in cervical cancer (87.5%) was higher than that in paracancerous tissues (14.1%), and the expression was positively correlated with clinical stage, malignant degree, lymphatic metastasis, vascular invasion and interstitial invasion. The expression of CBX7 protein in cervical cancer (48.4%) was lower than that in paracancerous tissues (96.8%), and the expression was negatively correlated with clinical stage, malignant degree, interstitial invasion, vascular invasion and lymphatic metastasis. The expression of Skp2 protein and CBX7 protein in cervical cancer tissues and adjacent tissues was negatively correlated. The expression of Skp2 and CBX7 proteins was closely related to the clinicopathological features of cervical cancer. Conclusions CBX7 may play the role of a tumour suppressor gene in cervical cancer and provide reference value for the diagnosis and new targeted treatment of cervical cancer.