Low coenzyme Q10 levels in patients with acute cardiovascular disease are associated with long-term mortality
Low coenzyme Q10 levels in patients with acute cardiovascular disease are associated with long-term mortality
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DOI：
10.1007/s00380-020-01698-7
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发表时间：
2020-09
影响因子：
1.5
通讯作者：
Megumi Shimizu;Tetsuro Miyazaki;Atsutoshi Takagi;Yurina Sugita;Shohei Ouchi;Tatsuro Aikawa;Tomoyuki Shiozawa-Tom
中科院分区：
文献类型：
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作者：
Megumi Shimizu;Tetsuro Miyazaki;Atsutoshi Takagi;Yurina Sugita;Shohei Ouchi;Tatsuro Aikawa;Tomoyuki Shiozawa-Tom
辅酶Q10（CoQ 10）通过改善细胞生物能量学在预防和治疗心血管疾病中发挥潜在作用。重症监护室中的危重病已被报道与循环辅酶Q10水平降低有关，我们以前证明了低辅酶Q10水平与住院死亡率的相关性。然而，辅酶Q10与心血管疾病急性期和长期死亡率的关系仍不清楚。我们连续招募了242例在顺天堂大学医院冠心病监护室住院的心血管疾病患者，以研究长期死亡率与血清CoQ 10水平之间的关系。在平均3.2年的随访中，58例患者死亡。非幸存者的平均血清CoQ 10水平显著低于幸存者（0.48 ± 0.27 vs. 0.58 ± 0.38 mg/L;p= 0.035）。与CoQ 10水平高于中位数（0.46 mg/L）的患者相比，CoQ 10水平较低的患者全因死亡率的累积发生率显著较高（p= 0.025）。多因素考克斯回归分析进一步表明，较低的辅酶Q10水平与不良预后相关。心血管疾病急性期低血清CoQ 10水平与患者的长期死亡率相关，表明低血清CoQ 10水平可作为预测因子和潜在治疗靶点。
Coenzyme Q10 (CoQ10) plays a potential role in the prevention and treatment of cardiovascular disease through improved cellular bioenergetics. Critical illness in the intensive care unit has been reported to be associated with decreased circulating CoQ10 levels, and we previously demonstrated the association of low CoQ10 levels with in-hospital mortality. However, the association of CoQ10 with the acute phase of cardiovascular disease and long-term mortality remains unclear. We enrolled 242 consecutive patients with cardiovascular disease admitted to the coronary care unit of Juntendo University Hospital to investigate the association between long-term mortality and serum CoQ10 levels. During a mean follow-up of 3.2 years, 58 patients died. The mean serum CoQ10 levels were significantly lower in the non-survivors than in the survivors (0.48 ± 0.27 vs. 0.58 ± 0.38 mg/L;p= 0.035). Compared with the patients with above-median CoQ10 levels (0.46 mg/L), the cumulative incidence of all-cause mortality was significantly higher in those with lower CoQ10 levels (p= 0.025). Multivariate Cox regression analysis further demonstrated that lower CoQ10 levels were associated with poor prognosis. Low serum CoQ10 levels during the acute phase of cardiovascular diseases were associated with long-term mortality in patients, suggesting the utility of low serum CoQ10 levels as a predictor and potential therapeutic target.