Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
复制标题
补充维生素 D 通过减少轻度认知障碍老年人端粒长度调节的氧化应激来改善认知功能：一项为期 12 个月的随机对照试验
DOI：
10.3233/jad-200926
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Fei Ma
中科院分区：
文献类型：
--
作者：
Tong Yang;Hualou Wang;Ying Xiong;Chong Chen;Keran Duan;Jingya Jia;Fei Ma
背景：老年人的认知能力下降是当今一个严重的公共卫生问题。维生素D补充剂与认知之间的关系仍然存在争议。目的：确定12个月的维生素D补充剂是否改善轻度认知障碍（MCI）老年受试者的认知功能，以及是否通过端粒长度（TL）调节氧化应激的机制介导。方法：这是一项在中国天津进行的双盲、随机、安慰剂对照试验。参与者均为母语为汉语的65岁及以上MCI患者。将183名受试者随机分为干预组（维生素D 800 IU/天，n = 93）或安慰剂组（匹配的淀粉颗粒，n = 90），并随访12个月。在基线、6个月和12个月时评估认知功能和机制相关生物标志物的测试。结果如下：重复测量方差分析显示，维生素D组在全量表智商（FSIQ）、信息、数字广度、词汇、区组设计和图片排列得分方面比安慰剂组有实质性改善（p
Background: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial. Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress. Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months. Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p