Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System.
Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System.
复制标题
紧急时空移位：蛋白激酶D对心血管系统中应力信号的反应。
DOI：
10.3389/fphar.2017.00009
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发表时间：
2017
影响因子：
5.6
通讯作者：
Bossuyt J
中科院分区：
文献类型：
--
作者：
Wood BM;Bossuyt J
蛋白激酶D亚型（PKD 1-3）是神经激素、氧化和代谢应激信号的关键介质。PKD影响多种信号传导途径和细胞功能，包括肌动蛋白动力学、囊泡运输、细胞运动性、存活、收缩性、能量底物利用和基因转录。PKD活性也越来越多地与癌症、免疫调节、疼痛调节、记忆、血管生成和心血管疾病相关。PKD功能的这种增加的复杂性和多样性突出了通过蛋白质-蛋白质相互作用、翻译后修饰或通过支架蛋白靶向对激酶进行严格时空控制的重要性。在这篇综述中，我们专注于PKD信号的时空调节和影响，神经激素，氧化剂和代谢信号，对心肌疾病的影响。这些机制的精确靶向将在基于PKD的治疗策略的设计中至关重要。
Protein Kinase D isoforms (PKD 1-3) are key mediators of neurohormonal, oxidative, and metabolic stress signals. PKDs impact a wide variety of signaling pathways and cellular functions including actin dynamics, vesicle trafficking, cell motility, survival, contractility, energy substrate utilization, and gene transcription. PKD activity is also increasingly linked to cancer, immune regulation, pain modulation, memory, angiogenesis, and cardiovascular disease. This increasing complexity and diversity of PKD function, highlights the importance of tight spatiotemporal control of the kinase via protein–protein interactions, post-translational modifications or targeting via scaffolding proteins. In this review, we focus on the spatiotemporal regulation and effects of PKD signaling in response to neurohormonal, oxidant and metabolic signals that have implications for myocardial disease. Precise targeting of these mechanisms will be crucial in the design of PKD-based therapeutic strategies.