Intrinsic Defense Mechanisms of the Intestinal Epithelium.
Intrinsic Defense Mechanisms of the Intestinal Epithelium.
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DOI：
10.1016/j.chom.2016.03.003
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发表时间：
2016-04-13
影响因子：
30.3
通讯作者：
Cadwell K
中科院分区：
文献类型：
--
作者：
Ramanan D;Cadwell K
肠道上皮是促进营养物质吸收的单一细胞层，但也为防止病原体入侵和共生微生物的传播提供了紧密的屏障。胃肠道的特化上皮细胞通过与淋巴样细胞、髓样细胞和基质细胞协同工作，分泌一系列限制上皮细胞与感染性病原体直接接触的因子，实现这一前线防御。肠道病原体以这些机制为靶点实现入侵和传播的能力，突显了这些机制的重要性。这篇综述强调了我们对这些复杂的分子和细胞机制的理解的最新进展，这些机制被这些细胞用来促进空间隔离和屏障维持。
The intestinal epithelium is a single cell layer that facilitates the absorption of nutrients but also provides a tight barrier to prevent pathogen invasion and dissemination of commensal microbes. Specialized epithelial cells of the gastrointestinal tract achieve this front-line defense by working in concert with lymphoid, myeloid, and stromal cells to secrete an array of factors that limit direct contact between the epithelium and infectious agents. The importance of these mechanisms is underscored by the ability of enteric pathogens to target these mechanisms to achieve invasion and dissemination. This review highlights recent advances in our understanding of these intricate molecular and cellular mechanisms adopted by these cells to promote spatial segregation and barrier maintenance.