Prognostic signs and the management of the mycosis fungoides
Prognostic signs and the management of the mycosis fungoides
复制标题
蕈样肉芽肿的预后体征和治疗
作者：
Z. Fuks;M. Bagshaw;E. Farber
共有132例经活检证实的蕈样肉芽肿患者接受了2.5 MeV电子全皮肤照射治疗。在58%的皮肤表现完全缓解观察。完全缓解率呈剂量依赖性，与疾病程度呈负相关。14例患者在单疗程治疗后的无病生存期为3-14年，可视为治愈。56例患者死亡，其中52%死于疾病的皮外累及。皮外受累与皮肤受累的程度、初始淋巴结病的存在相关，并与不良预后相关。提出了一种新的分期分类，为蕈样肉芽肿患者的新治疗方法的引入提供了合理的依据。
A total of 132 patients with biopsy‐proven mycosis fungoides were treated by total skin irradiation with 2.5 MeV electrons. In 58% a complete remission of cutaneous manifestations was observed. The rate of complete remission was dose‐dependent and was inversely dependent on the extent of disease. Fourteen patients had disease‐free survivals of 3–14 years following a single course of treatment, and may be considered as cured. Fifty‐six patients died, 52% of whom succumbed to extracutaneous involvement with disease. Extracutaneous involvement correlated with the extent of skin involvement, and with the presence of initial lymphadenopathy, and was associated with poor prognosis. A new staging classification is proposed which provides a rational basis for the introduction of new treatment modalities for the management of mycosis fungoides patients.