Neural activity in the prelimbic and infralimbic cortices of freely moving rats during social interaction: Effect of isolation rearing.
Neural activity in the prelimbic and infralimbic cortices of freely moving rats during social interaction: Effect of isolation rearing.
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DOI：
10.1371/journal.pone.0176740
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Mitani A
中科院分区：
文献类型：
--
作者：
Minami C;Shimizu T;Mitani A
社交促进个人健康的日常生活。社交能力下降是各种神经精神疾病的核心症状，但社交能力下降背后的神经机制尚不清楚。前边缘皮层（PL）和下边缘皮层（IL）被认为在社交能力的神经机制中起着重要作用，因为隔离饲养会导致大鼠的社交行为受损和前边缘皮层和下边缘皮层的结构变化。社交能力下降的一个可能机制涉及前边缘皮层和下边缘皮层的功能障碍。我们制作了一个无线遥测系统来记录一对自由运动的大鼠在社交互动和社交过程中的前边缘皮层和下边缘皮层的多单元活动考察了隔离饲养对这一活性的影响。在集体饲养的大鼠中，当大鼠表现出接近行为和接触行为时，特别是当大鼠攻击同伴时，PL神经元的放电增加。相反，当大鼠表现出离开行为时，尤其是当伴侣自愿离开时，IL神经元会增加放电。在社会交往中，前向者可能参与对他人的主动行动，而后向者可能参与对警告性被试的被动救济。孤立抚养改变了社会行为和神经活动。隔离饲养的大鼠出现接触行为的频率增加，持续时间缩短。在隔离饲养的大鼠中，在接近和接触行为中观察到的PL神经元的放电增加在隔离饲养的大鼠中被保留，而在隔离饲养的大鼠中观察到的离开行为中IL神经元的放电增加在隔离饲养的大鼠中被抑制。这一结果表明，隔离饲养在社会行为过程中对左脑和左脑的神经活动有不同程度的改变。隔离饲养对前庭和后庭神经活动的差异影响可能是隔离饲养诱导行为的神经基础之一。
Sociability promotes a sound daily life for individuals. Reduced sociability is a central symptom of various neuropsychiatric disorders, and yet the neural mechanisms underlying reduced sociability remain unclear. The prelimbic cortex (PL) and infralimbic cortex (IL) have been suggested to play an important role in the neural mechanisms underlying sociability because isolation rearing in rats results in impairment of social behavior and structural changes in the PL and IL. One possible mechanism underlying reduced sociability involves dysfunction of the PL and IL. We made a wireless telemetry system to record multiunit activity in the PL and IL of pairs of freely moving rats during social interaction and examined the influence of isolation rearing on this activity. In group-reared rats, PL neurons increased firing when the rat showed approaching behavior and also contact behavior, especially when the rat attacked the partner. Conversely, IL neurons increased firing when the rat exhibited leaving behavior, especially when the partner left on its own accord. In social interaction, the PL may be involved in active actions toward others, whereas the IL may be involved in passive relief from cautionary subjects. Isolation rearing altered social behavior and neural activity. Isolation-reared rats showed an increased frequency and decreased duration of contact behavior. The increased firing of PL neurons during approaching and contact behavior, observed in group-reared rats, was preserved in isolation-reared rats, whereas the increased firing of IL neurons during leaving behavior, observed in group-reared rats, was suppressed in isolation-reared rats. This result indicates that isolation rearing differentially alters neural activity in the PL and IL during social behavior. The differential influence of isolation rearing on neural activity in the PL and IL may be one of the neural bases of isolation rearing-induced behavior.