A Test in Context: Critical Evaluation of Natriuretic Peptide Testing in Heart Failure.
A Test in Context: Critical Evaluation of Natriuretic Peptide Testing in Heart Failure.
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DOI：
10.1016/j.jacc.2015.10.073
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发表时间：
2016-01-26
影响因子：
24
通讯作者：
Tang WH
中科院分区：
文献类型：
--
作者：
Francis GS;Felker GM;Tang WH
在过去的15年里，循环利钠肽测量被广泛用于诊断和监测心力衰竭患者。我们仍在学习如何复杂的动态利钠肽可以在个别患者的测试结果的解释。虽然利钠肽测量在实践中被广泛使用，但关于为什么这些肽不一定与个体患者的血容量或侵入性血流动力学测量相跟踪存在问题。利钠肽测量结果的解释取决于许多因素，包括特殊的患者群体、肥胖、肾功能、充血或去充血状态，以及患者是否接受了特定的治疗。利钠肽测量显然已经彻底改变了心力衰竭患者的临床护理，但进一步的研究应该提供见解，以帮助使用这些测量来个性化患者护理，而不是目前的指导方针。
Circulating natriuretic peptide measurements have been used extensively over the past 15 years to diagnose and monitor patients with heart failure. We are still learning how complex the dynamics of natriuretic peptides can be in the interpretation of test results in individual patients. Although natriuretic peptide measurements are widely used in practice, there are questions regarding why these peptides may not necessarily track with blood volume or invasive hemodynamic measurements in individual patients. Interpretation of natriuretic peptide measurements will depend on many factors, including special patient populations, obesity, renal function, the state of congestion or decongestion, and whether patients are receiving specific therapies. Natriuretic peptide measurements have clearly revolutionized clinical care for patients with heart failure, but further research should provide insights to help use these measurements to individualize patient care beyond the current guidelines.