Reduced Sympathetic Innervation in Endometriosis is Associated to Semaphorin 3C and 3F Expression
Reduced Sympathetic Innervation in Endometriosis is Associated to Semaphorin 3C and 3F Expression
复制标题
子宫内膜异位症交感神经支配减少与信号蛋白3C和3F表达有关
DOI：
10.1007/s12035-016-0058-1
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发表时间：
2017-09-01
影响因子：
5.1
通讯作者：
Mechsner, Sylvia
中科院分区：
文献类型：
--
作者：
Scheerer, Claudia;Frangini, Sergio;Mechsner, Sylvia
子宫内膜异位症是一种慢性炎症性疾病，也是引起盆腔疼痛的最常见原因之一。子宫内膜异位症期间疼痛出现或慢性炎症的机制尚不清楚。包括子宫内膜异位症在内的几种慢性炎症性疾病显示去甲肾上腺素能神经纤维数量减少。受影响的神经来源仍不清楚。信号素是潜在的诱导物，因为它们是已知的轴突引导信号，在不同的慢性炎症性疾病中被认为是神经排斥因子。因此，信号素可能影响子宫内膜异位症神经炎性机制的进展。在这里，我们分析了去甲肾上腺素的神经支配以及可能参与子宫内膜异位症神经免疫调节的特异性信号素和受体的表达。我们的研究发现，腹膜异位内膜组织中的神经支配受到影响，信号素及其受体显着增加。从而确定受体在去甲肾上腺素能神经纤维和血管膜上的表达。在腹膜异位内膜组织中，巨噬细胞和活化的成纤维细胞密度较高，并表达信号素。炎症导致免疫细胞的释放增加，免疫细胞分泌各种能够影响神经支配的炎症因子。因此，我们的数据提示，子宫内膜异位症的慢性炎症状态可能参与了信号素的增加，这可能影响了腹膜内异症的神经支配。
Endometriosis is a chronic inflammatory disease and one of the most common causes of pelvic pain. The mechanisms underlying pain emergence or chronic inflammation during endometriosis remain unknown. Several chronic inflammatory diseases including endometriosis show reduced amounts of noradrenergic nerve fibers. The source of the affected innervation is still unclear. Semaphorins represent potential elicitors, due to their known role as axonal guidance cues, and are suggested as nerve repellent factors in different chronic inflammatory diseases. Therefore, semaphorins might influence the progress of neuroinflammatory mechanisms during endometriosis. Here, we analyzed the noradrenergic innervation and the expression of the specific semaphorins and receptors possibly involved in the neuroimmunomodulation in endometriosis. Our studies revealed an affected innervation and a significant increase of semaphorins and their receptors in peritoneal endometriotic tissue. Thereby, the expression of the receptors was identified on the membrane of noradrenergic nerve fibers and vessels. Macrophages and activated fibroblasts were found in higher density levels and additionally express semaphorins in peritoneal endometriotic tissue. Inflammation leads to an increased release of immune cells, which secrete a variety of inflammatory factors capable of affecting innervation. Therefore, our data suggests that the chronic inflammatory condition in endometriosis might contribute to the increase of semaphorins, which could possibly affect the innervation in peritoneal endometriosis.