DNA sensing using split-ring resonator alone at microwave regime
DNA sensing using split-ring resonator alone at microwave regime
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DOI：
10.1063/1.3459877
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发表时间：
2010-07-01
影响因子：
3.2
通讯作者：
Yook, Jong-Gwan
中科院分区：
文献类型：
--
作者：
Lee, Hee-Jo;Lee, Hyun-Seok;Yook, Jong-Gwan
本文论证了单元件双分裂环谐振器作为生物传感器件的可行性。紧凑型谐振器是由50欧米伽微带传输线产生的时变磁场激励的。在这项工作中，DNA杂交是通过S-21共振频率的偏移来识别的。将硫醇连接的单链DNA固定在金(Au)表面，然后与互补DNA偶联，其频率变化分别为Delta积分(ss-DNA)=20 MHz和Delta积分(杂交)=60 MHz。由此可见，该谐振器在微波条件下可作为DNA传感元件使用。(C)2010年美国物理研究所。[DOI：10.1063/1.3459877]
In this paper, the feasibility of utilization of a single element double split-ring resonator as a biosensing device has been demonstrated. The compact resonator has been excited by time-varying magnetic fields generated from the 50 Omega microstrip transmission line. In this work, DNA hybridization is recognized with shift in S-21 resonant frequency. When thiol-linked single stranded-DNA is immobilized onto a gold (Au) surface and is then coupled with complementary-DNA, the frequency changes by Delta integral(ss-DNA)=20 MHz and Delta integral(hybridization)=60 MHz, respectively. Thus, it is clear that the resonator can be utilized as a DNA sensing element in the microwave regime. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3459877]