Mimicking Spray Drying by Drying of Single Droplets Deposited on a Flat Surface
Mimicking Spray Drying by Drying of Single Droplets Deposited on a Flat Surface
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DOI：
10.1007/s11947-011-0767-4
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发表时间：
2013-04-01
影响因子：
5.6
通讯作者：
Boom, Remko M.
中科院分区：
文献类型：
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作者：
Perdana, Jimmy;Fox, Martijn B.;Boom, Remko M.
生物活性成分在喷雾干燥过程中的失活通常是基质特异性的。因此，新工艺的设计或现有喷雾干燥工艺的优化通常是高度产品特异性的，需要大量的实验。因此，需要能够促进快速数据生成的快速实验方法。提出了一种模拟喷雾干燥的单液滴干燥新方法。该方法包括在疏水平面上沉积液滴，然后进行控制干燥。采用传热传质模型对单个液滴的干燥过程进行了预测。通过研究-半乳糖苷酶在干燥过程中的失活情况，成功地对该方法进行了评价。结合失活动力学的传热传质模型可以合理地预测干燥后酶的剩余活性。此外，可以直接从单液滴实验中提取失活动力学，而不是使用单独加热实验的动力学。最后，证明了单滴实验的失活动力学可以很好地预测实验室规模的喷雾干燥机干燥-半乳糖苷酶的残留活性。
The inactivation of bioactive ingredients during spray drying is often matrix specific. Therefore, the design of new processes or the optimisation of existing spray drying processes is usually highly product specific and requires numerous experiments. Rapid experimentation methods that facilitate fast data generation are therefore desired. A novel method for drying single droplets to mimic spray drying is proposed. The approach involves droplet deposition on a hydrophobic flat surface followed by controlled drying. A heat and mass transfer model is applied to predict the drying history of the single droplets. The approach is successfully evaluated through studying the inactivation of beta-galactosidase during drying. The heat and mass transfer model supplemented with inactivation kinetics provided reasonable prediction of the residual enzyme activity after drying. In addition, the inactivation kinetics could be directly extracted from single droplet experiments rather than using the kinetics from separate heating experiments. Finally, it was demonstrated that the inactivation kinetics found with the single-drop experiments could satisfactorily predict the residual activity of beta-galactosidase dried with a laboratory-scale spray dryer.