Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics.
Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics.
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DOI：
10.3389/fcimb.2018.00034
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发表时间：
2018
影响因子：
5.7
通讯作者：
Costa FTM
中科院分区：
文献类型：
--
作者：
Bourgard C;Albrecht L;Kayano ACAV;Sunnerhagen P;Costa FTM
在过去的十年里，广阔的组学领域使生物学研究发生了革命性的变化，特别是基因组学、转录组学和蛋白质组学分支，因为现场研究人员可以使用技术工具，并使困难的问题驱动研究得以解决。寄生虫学得益于下一代测序(NGS)计划，这些计划使人们对基础寄生虫分子生物学、生态学和流行病学有了更广泛的理解。疟疾学是这项技术的应用极大地有助于更好地了解疟原虫的一个例子。生物学和寄主-寄生虫的相互作用。在导致人类疟疾的几种寄生虫中，被忽视的间日疟原虫带来了巨大的研究挑战，因为体外培养尚不可行，功能分析严重受限。因此，我们的间日疟原虫生物学知识存在空白，这影响了旨在在不久的将来根除间日疟的控制政策的决策。在这篇综述中，我们提供了间日疟原虫测序项目已经取得的主要发现的快照，重点是研究社区目前面临的发展、障碍和限制，以及对未来间日疟研究的展望。
During the last decade, the vast omics field has revolutionized biological research, especially the genomics, transcriptomics and proteomics branches, as technological tools become available to the field researcher and allow difficult question-driven studies to be addressed. Parasitology has greatly benefited from next generation sequencing (NGS) projects, which have resulted in a broadened comprehension of basic parasite molecular biology, ecology and epidemiology. Malariology is one example where application of this technology has greatly contributed to a better understanding of Plasmodium spp. biology and host-parasite interactions. Among the several parasite species that cause human malaria, the neglected Plasmodium vivax presents great research challenges, as in vitro culturing is not yet feasible and functional assays are heavily limited. Therefore, there are gaps in our P. vivax biology knowledge that affect decisions for control policies aiming to eradicate vivax malaria in the near future. In this review, we provide a snapshot of key discoveries already achieved in P. vivax sequencing projects, focusing on developments, hurdles, and limitations currently faced by the research community, as well as perspectives on future vivax malaria research.