Targeted naltrexone for problem drinkers.
Targeted naltrexone for problem drinkers.
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有针对性的纳曲酮用于饮酒者。
DOI：
10.1097/jcp.0b013e3181ac5213
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发表时间：
2009-08
影响因子：
2.9
通讯作者：
Oncken C
中科院分区：
文献类型：
--
作者：
Kranzler HR;Tennen H;Armeli S;Chan G;Covault J;Arias A;Oncken C
这项研究旨在复制和扩展先前的研究，表明有针对性地使用纳洛酮是减少大量饮酒的有用策略。我们比较了纳洛酮与安慰剂在163名个体（58.3%男性）样本中的作用，这些个体的目标是将饮酒量减少到安全范围。患者接受研究药物（即，纳洛酮50 mg或安慰剂），并指导他们每天使用或针对他们确定为重度饮酒高风险的情况使用。在为期12周的试验中，使用交互式语音应答（IVR）系统获得每日饮酒和药物使用报告。使用分层线性模型进行分析，性别作为潜在的调节变量。在第12周的主要结果指标，即每天平均饮酒量，目标纳洛酮组的男性饮酒量明显低于其他组的患者。在第12周期间，在次要结果测量中，每饮酒日的饮酒量，目标纳洛酮组的饮酒量显著低于其他组，性别没有调节作用。这些结果支持使用有针对性的方法来减少重度饮酒者，特别是男性的饮酒量，但主张使用额外的策略或更有效的药物来增加这种干预的效果。
This study aimed to replicate and extend prior research showing that the targeted use of naltrexone is a useful strategy to reduce heavy drinking. We compared the effects of naltrexone with those of placebo in a sample of 163 individuals (58.3% male) whose goal was to reduce their drinking to safe limits. Patients received study medication (i.e., naltrexone 50 mg or placebo) and were instructed to use it either daily or targeted to situations identified by them as being high risk for heavy drinking. An interactive voice response (IVR) system was used to obtain daily reports of drinking and medication use during the 12-week trial. Analyses were conducted using hierarchical linear modeling, with sex as a potential moderator variable. On the primary outcome measure, mean drinks per day, at week 12, men in the targeted naltrexone group drank significantly less than patients in the other groups. On a secondary outcome measure, drinks per drinking day, during week 12, the targeted naltrexone group drank significantly less than the other groups, with no moderating effect of sex. These results support the use of a targeted approach to reduce drinking among heavy drinkers, particularly men, but argue for the use of additional strategies or more efficacious medications to increase the effects of such an intervention.