Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population.
Association of Metabolic Syndrome With Glaucoma and Ocular Hypertension in a Midwest United States Population.
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DOI：
10.1097/ijg.0000000000001968
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发表时间：
2022-06-01
影响因子：
2
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确定代谢综合征患者是否更容易发生青光眼性视神经病变（也称为青光眼）和高眼压。基于诊断代码、实验室值和/或药物使用，将美国明尼苏达州奥姆斯特德县的患者确定为患有代谢综合征，以满足诊断代谢综合征的五个标准标准中的三个或更多个：全身性高血压、高血糖症、高脂血症、降低的高密度脂蛋白胆固醇和通过增加的体重指数定义的中心性肥胖。青光眼患者，包括原发性开角型、低眼压、色素弥散和假性剥脱，使用诊断代码进行识别。对青光眼患者的视力、眼压、杯盘比、中央角膜厚度、视野平均偏差、视网膜神经纤维层厚度和眼压治疗进行了单独审查。高眼压患者被单独识别并进行类似的评价。在青光眼患者中，与无代谢综合征的患者相比，代谢综合征患者的眼压和中央角膜厚度较高。校正中央角膜厚度后，组间眼压不再有显著差异。代谢综合征也与高眼压的诊断相关，尽管代谢综合征患者的中央角膜厚度有升高的趋势，但没有达到统计学意义。在奥姆斯特德县，虽然代谢综合征与青光眼患者的高眼压和高眼压相关，但结果可能与该患者人群的中央角膜厚度较厚有关。对于昏迷性视神经病变患者，代谢综合征与高眼压和高中央角膜厚度相关。患有代谢综合征的患者也更可能患有高眼压症。
To determine whether glaucomatous optic neuropathy, also known as glaucoma, and ocular hypertension are more likely to occur in patients with metabolic syndrome. Patients in Olmsted County, MN, USA were identified as having metabolic syndrome based on diagnosis codes, laboratory values, and/or medication use to meet three or more of the five standard criteria for diagnosing metabolic syndrome: systemic hypertension, hyperglycemia, hypertriglyceridemia, reduced high density lipoprotein cholesterol, and central adiposity defined by increased body mass index. Patients with glaucoma, including primary open angle, low tension, pigment dispersion, and pseudoexfoliation, were identified using diagnostic codes. The charts of patients with glaucoma were individually reviewed to collect visual acuity, intraocular pressure, cup to disc ratio, central corneal thickness, visual field mean deviation, retinal nerve fiber layer thickness, and treatment of intraocular pressure. Patients with ocular hypertension were separately identified and similarly evaluated. In patients with glaucoma, those with metabolic syndrome had higher intraocular pressure and central corneal thickness compared to those without metabolic syndrome. After adjustment for central corneal thickness, there was no longer a significant difference in intraocular pressure between groups. Metabolic syndrome was also associated with the diagnosis of ocular hypertension, and although central corneal thickness trended higher in patients with metabolic syndrome, it did not attain statistical significance. In Olmsted County, though metabolic syndrome was associated with ocular hypertension and higher intraocular pressure in patients with glaucoma, the results were likely related to a thicker central corneal thickness in this patient population. For patients with glaucomatous optic neuropathy, metabolic syndrome was associated with higher intraocular pressure and higher central corneal thickness. Patients with metabolic syndrome were also more likely to have ocular hypertension.