Analysis on herbal medicines utilized for treatment of COVID-19
Analysis on herbal medicines utilized for treatment of COVID-19
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DOI：
10.1016/j.apsb.2020.05.007
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发表时间：
2020-07-01
影响因子：
14.5
通讯作者：
Chen, Shilin
中科院分区：
文献类型：
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作者：
Luo, Lu;Jiang, Jingwen;Chen, Shilin
由于2019冠状病毒病（COVID-19）大流行对全球公共卫生构成重大威胁，中国91. 50%的COVID-19病例使用了中医药，在改善症状管理和降低恶化、死亡率和复发率方面取得了令人鼓舞的成果。在中国，共收集了166种改良草药配方，包括179种单一草药，用于治疗COVID-19。临床应用最多的是黄芪、丹参、苦杏仁，传统描述中以解热（47例，占26.26%）、祛痰止咳（22例，占12.29%）、化湿（21例，占11.73%）为主。初步筛选出含β-谷甾醇、豆甾醇、槲皮素等1212种化学成分。此外，使用复杂系统熵和无监督层次聚类，8种核心草药组合和10种新配方成为COVID-19的潜在有用候选者。最后，经过支架分析，自组织映射（SOM）和聚类分析，12个分子簇产生了8个药效团结构家族，这些结构家族被进一步筛选为人类代谢途径中抑制冠状病毒的药理学靶标。本文旨在以现代方式更容易获得和分享用于当代治疗的历史草药知识，以帮助研究人员遏制COVID-19的全球传播。(C)2020中国药学会、中国医学科学院药物研究所。制作和主办：Elsevier B. V.
As coronavirus disease 2019 (COVID-19) pandemic poses a substantial global public health threat, traditional Chinese medicine (TCM) was used in 91.50% of the COVID-19 cases in China, showing encouraging results in improving symptom management and reducing the deterioration, mortality, and recurrence rates. A total of 166 modified herbal formulae consisting of 179 single herbal medicines were collected for treating COVID-19 in China. Glycyrrhizae Radix et Rhizome, Scutellariae Radix, and Armeniacae Semen Amarum are the most frequently utilized in clinics, most of which are antipyretic (47, 26.26%), expectorant and cough- suppressing (22, 12.29%), and dampness-resolving (21, 11.73%) from traditional descriptions. A total of 1212 chemical components containing beta-sitosterol, stigmasterol, and quercetin were primarily selected. Additionally, using complex system entropy and unsupervised hierarchical clustering, 8 core herbal combinations and 10 newformulae emerged as potentially useful candidates for COVID-19. Finally, following scaffold analysis, self-organizing mapping (SOM) and cluster analysis, 12 clusters of molecules yielded 8 pharmacophore families of structures that were further screened as pharmacological targets in human metabolic pathways for inhibiting coronavirus. This article aims to make more easily accessible and share historical herbal knowledge used in contemporary treatments in a modern manner to assist researchers contain the global spread of COVID-19. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.