Possibility of Combining Carbon Dots and Liquid Exfoliated Graphene as a Carbon-Based Light Addressable Potentiometric Sensor
Possibility of Combining Carbon Dots and Liquid Exfoliated Graphene as a Carbon-Based Light Addressable Potentiometric Sensor
复制标题
将碳点和液态剥离石墨烯组合作为碳基光可寻址电位传感器的可能性
DOI：
10.1021/acssensors.0c02515
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发表时间：
2021-02-05
期刊：
影响因子：
8.9
通讯作者：
Jia, Yunfang
中科院分区：
文献类型：
--
作者：
Li, Fang;Zhang, Jizhao;Jia, Yunfang
光寻址电位传感器（LAPS）是一种多功能的生物检测传感平台。然而，碳基LAPS（C-LAPS）的缺乏是其在碳电子时代可持续发展的瓶颈。在此，提出了基于碳量子点（CD）和液体剥离石墨烯（LEG）的组合的C-LAPS的研究。首先通过水热合成的CD和共溶剂超声剥离的LEG在聚二烯丙基二甲基氯化铵（PDDA）修饰的氧化铟锡（ITO）玻璃上自组装制备了C-LAPS器件。根据CD和LEG的堆叠顺序，CLAPS被命名为CD/LEG@PDDA/ITO和LEG/CD @PDDA/ITO。然后，它们的电子和光电特性进行了测量，并与纯CD和纯LEG-decorated ITO电极进行了比较。利用能带弯曲和内建电场的经典理论，分析了其工作机理。从光生载流子的产生和分离、光电流的形成以及与LEG/CDs@PDDA/ITO的区别等方面证实了CD/LEG@PDDA/ITO基C-LAPS与Si基LAPS（Si-LAPS）的相似性。最后，通过5-甲基胞嘧啶（5 mC）及其抗体（抗5 mC）的免疫反应证明其生物学应用的可行性。通过与Si-LAPS的结果进行比较，证明了改进的线性响应。最后，建议C-LAPS被认为是一个候选人的传统的基于半导体的LAPS，具有解决方案可处理的优点。同时，对C-LAPS原理的理论推导也为开发类似的碳基传感器奠定了基础。
A light addressable potentiometric sensor (LAPS) is a versatile sensing platform for bioassay. However, the lack of carbon-based LAPS (C-LAPS) is a bottleneck for its sustainable development in a carbon electronic era. Herein, a study of C-LAPS based on the combinations of carbon dots (CDs) and liquid exfoliated graphene (LEG) is presented. Devices of C-LAPS are first fabricated by self-assembling the hydrothermally synthesized CDs and the cosolvent ultrasonic delaminated LEG on poly(diallyldimethylammonium chloride) (PDDA)-modified indium tin oxide (ITO) glasses. According to the stacking orders of CDs and LEG, CLAPS are named as CDs/LEG@PDDA/ITO and LEG/CDs@PDDA/ITO. Then, their electronic and photoelectronic features are measured and compared with the pure CD- and pure LEG-decorated ITO electrodes. Furthermore, working mechanisms are proposed by means of the classical theories of energy band bending and built-in electric field at the heterojunction of CDs and LEG. The resemblances of CDs/LEG@PDDA/ITO-based C-LAPS with Si-based LAPS (Si-LAPS) are confirmed from the points of view of production and separation of the photogenerated carriers, the formation of photocurrent, and the distinction with LEG/CDs@PDDA/ITO. Finally, its feasibility for biological application is justified by using the immune reaction of 5-methylcytosine (5mC) and its antibody (anti-5mC) as a proof of concept. The improved linear responses are evidenced by the comparisons with Si-LAPS' results. Conclusively, the proposed C-LAPS is believed to be a candidate for traditional semiconductor-based LAPS, with the merit of solutionprocessable. Meanwhile, the theoretical deductions about C-LAPS' principle can also pave the way for developing similar carbonbased sensors.