International variation
International variation
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DOI：
10.1038/sj.onc.1207726
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发表时间：
2004-08-23
期刊：
影响因子：
8
通讯作者：
Parkin, DM
中科院分区：
文献类型：
--
作者：
Parkin, DM
2000年估计有1 000万新病例，600万人死亡，2 200万人患有癌症。就新发病例而言，最常见的癌症是肺癌（120万）、乳腺癌（105万）、结肠直肠（94.5万）、胃癌（87.6万）和肝癌（56.4万）。本文总结了已作出国家估计的约20种癌症的地理分布情况。从暴露于致癌物（在外部环境中或通过生活方式的选择）或对致癌物的遗传易感性方面的差异来看，对这些模式的可能原因进行了检查。来自移民人口研究的相关数据（允许对生活在不同环境中的基因相似的人口进行比较）和来自生活在同一国家的不同种族群体之间的比较，被用来帮助解释地理模式。关于疾病负担的信息在规划和监测癌症控制方案方面也具有非常重要的作用。
There were an estimated 10 million new cases, 6 million deaths and 22 million persons living with cancer in the year 2000. The most common cancers are, in terms of new cases, lung (1.2 million), breast (1.05 million), colon rectum (945000), stomach (876 000) and liver (564 000). The geographic distributions of some 20 types of cancer for which national estimates have been made are summmarized. These patterns are examined with respect to the likely reasons in terms of variation in exposure to carcinogens (in the external environment or through lifestyle choices) or in genetic susceptibility to them. Related data from studies of migrant populations (that allow comparisons of genetically similar populations living in different environments) and from comparisons between different ethnic groups living in the same country are used to help in the interpretation of the geographic patterns. Information on the burden of disease also has a very important role in the planning and monitoring of programmes of cancer control.