Incidence rate of primary cardiac tumors: a 14-year population study
Incidence rate of primary cardiac tumors: a 14-year population study
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DOI：
10.2459/jcm.0000000000000059
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发表时间：
2016-01-01
影响因子：
3
通讯作者：
Severi, Silva
中科院分区：
文献类型：
--
作者：
Cresti, Alberto;Chiavarelli, Mario;Severi, Silva
原发性心脏肿瘤的发病率尚不清楚。文献数据来自尸检研究或超声心动图登记研究。报告了1/1000例尸检和1.5/1000例超声心动图研究的发生率，但未获得一般人群的数据。我们的研究的目的是评估的发病率PCTs在一般population.MethodsAll可疑心脏肿块的患者进行了评估与基础超声心动图和/或经食管超声心动图/心脏磁共振由格罗塞托的心脏科，县转诊中心为成人和儿童人群。诊断在手术切除（32例）、尸检标本（3例）或不需要手术时通过多模式成像（7例）得到证实。查询县卫生系统的数据库，以确定居民与国际疾病分类-PCT的9个代码。从1998年1月1日至2011年12月31日，在格罗塞托县的居民中诊断出42例连续的PCTs。38例患者（90.5%）为良性PCT，4例患者（9.5%）为恶性PCT。粘液瘤20例（48%），其次是纤维瘤7例（15%），脂肪瘤6例（15%），横纹肌瘤3例（8%），血管瘤2例（5%），肉瘤2例（5%），淋巴瘤1例（2%），心包血管外皮细胞瘤1例（2%）。良性PCT的发病率为1.24的100,000/year;仅指粘液瘤，我们发现的发病率为0.68的100,000/year.ConclusionThis是第一个人口研究PCT，一种罕见的疾病，发病率为1.38每10万居民每年的新病例。
AimsIncidence of primary cardiac tumors (PCTs) is not known. Literature data derive from autoptic studies or echocardiographic registries. An incidence of 1 of 1000 autoptic and 1.5 of 1000 echocardiographic study is reported but data from a general population are not available. The aim of our study was to evaluate the incidence rate of PCTs in the general population.MethodsAll patients with suspected cardiac mass were evaluated with basal echocardiogram and/or transesophageal echocardiogram/cardiac magnetic resonance by Grosseto's cardiology department, the county referral center for both adult and pediatric populations. Diagnosis was confirmed at surgical excision (32), autoptic specimens (3) or by multimodal imaging when surgery was not indicated (7). The database of the county health system was interrogated to identify residents with The International Classification of Diseases-9 codes of PCT. Forty-two consecutive cases of PCTs were diagnosed from 1 January 1998, through 31 December 2011, among residents in Grosseto's county.ResultsIncidence rate of PCTs was 1.38 of 100000 inhabitants per year. PCTs were benign in 38 patients (90.5%) and malignant in four (9.5%). Twenty myxomas were found (48%), followed by seven fibroelastomas (15%), six lipomas (15%), three rhabdomyomas (8%), two hemangioma (5%), two sarcomas (5%), one lymphoma (2%) and one pericardial hemangiopericytoma (2%). Incidence of benign PCT was 1.24 of 100000/year; referring only to myxomas we found an incidence of 0.68 of 100000/year.ConclusionThis is the first population study on PCT, a rare disease with an incidence rate of 1.38 new cases per 100,000 residents per year.