Resistant Streptococcus pneumoniae strains in children with acute otitis media- high risk of persistent colonization after treatment.
Resistant Streptococcus pneumoniae strains in children with acute otitis media- high risk of persistent colonization after treatment.
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DOI：
10.1186/s12879-018-3398-9
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发表时间：
2018-09-25
影响因子：
3.7
通讯作者：
Malm A
中科院分区：
文献类型：
--
作者：
Korona-Glowniak I;Zychowski P;Siwiec R;Mazur E;Niedzielska G;Malm A
Despite advances in the development of pneumococcal conjugate vaccines, acute otitis media (AOM) is a common childhood infection, caused mainly by Streptococcus pneumoniae. It has been suggested that persistence of pneumococcal nasopharyngeal carriage is a risk factor for subsequent recurrent infections. In this study we evaluate the relationship between 55 pneumococcal strains obtained from nasopharynx/oropharynx (NP/OP) and middle ear fluid (MEF) of 62 children, aged between 1 and 16 years, during AOM (including recurrent/treatment failure AOM, and post-treatment visits), based on their phenotypic and genotypic characteristics performed by analyses of serotype, antibiotic susceptibility patterns and multilocus sequence typing. S.pneumoniae was isolated from 27.4% of MEF samples; it constituted 43.6% of all positive bacterial samples from MEF samples. There was statistically significant concordance between isolation from the MEF sample and NP/OP colonization by S. pneumoniae (p < 0.0001). During post-treatment visits S.pneumoniae was isolated from 20.8% of children; 91% of them were positive in pneumococcal NP/OP culture during AOM. The serotypes belonging to 10- and 13-valent pneumococcal conjugate vaccines constituted 84% and 92% of the strains, respectively. Multidrug resistance was found in 84% of the strains. According to multivariate analysis, pneumococcal colonization after antibiotic therapy was significantly associated with shorter length of therapy in children with bilateral AOM. High persistent prevalence of antibiotic-resistant S.pneumoniae strains in children with AOM after unsuccessful bacterial eradication may presumably be regarded as a predisposing factor of infection recurrence. The online version of this article (10.1186/s12879-018-3398-9) contains supplementary material, which is available to authorized users.
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影响因子：
3.6
作者：
McCormick, DP;Lim-Melia, E;Chonmaitree, T
通讯作者：
Chonmaitree, T
影响因子：
3.6
作者：
PICHICHERO, ME;PICHICHERO, CL
通讯作者：
PICHICHERO, CL
影响因子：
3.7
作者：
Korona-Glowniak I;Maj M;Siwiec R;Niedzielski A;Malm A
通讯作者：
Malm A
影响因子：
9.4
作者：
McGee, L;McDougal, L;Klugman, KP
通讯作者：
Klugman, KP
影响因子：
11.8
作者：
Palmu, AAI;Herva, E;Kilpi, TM
通讯作者：
Kilpi, TM