Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
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DOI：
10.1001/jama.287.2.195
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发表时间：
2002-01-09
影响因子：
120.7
通讯作者：
Xu, XP
中科院分区：
文献类型：
--
作者：
Wang, XB;Zuckerman, B;Xu, XP
吸烟的遗传易感性与不良妊娠结局的关系尚不清楚。目的探讨母体代谢基因CYP1A1和GSTT1多态性是否与母体吸烟与婴儿出生体重的关系存在差异。设计、环境和参与者：1998-2000年在波士顿医疗中心进行的一项病例对照研究，研究对象为741名母亲（174名曾经吸烟，567名从未吸烟），这些母亲都是单胎活产。207例为早产儿或低出生体重儿，534例为非低出生体重、足月儿（对照组）。主要结局指标：出生体重、妊娠、胎儿生长与吸烟状况和CYP1A1 Mspl （AA vs AA和AA，其中AA和as合并，因为as数量少，结果相似）以及GSTT1（存在vs不存在）基因型有关。结果在不考虑基因型的情况下，孕期持续吸烟与新生儿出生体重平均减少377 g （SE, 89 g）相关（优势比[OR]， 2.1； 95%可信区间[CI]， 1.2-3.7）。当考虑CYP1A1基因型时，AA基因型组的出生体重估计减少252 g (SE, 111 g) (n = 75； OR, 1.3; 95% CI, 0.6-2.6)；Aa/ Aa基因型组为520 g (SE为124 g) （Aa组n=43， Aa组n=6； OR为3.2；95% CI为1.6 ~ 6.4）。当考虑GSTT1基因型时，存在和缺失基因型组的出生体重估计减少分别为285 g (SE, 99 g) （OR, 1.7; 95% CI, 0.9-3.2）和642 g (SE, 154 g) （OR, 3.5; 95% Cl, 1.5-8.3）。当同时考虑CYP1A1和GSTT1基因型时，发现CYP1A1 Aa/ Aa和GSTT1基因型缺失的吸烟母亲出生体重下降最大(-1285 g； SE, 234 g； P
Context Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes.Objective To investigate whether the association between maternal cigarette smoking and infant birth weight differs by polymorphisms of 2 maternal metabolic genes: CYP1A1 and GSTT1.Design, Setting, and Participants Case-control study conducted in 1998-2000 among 741 mothers (174 ever smokers and 567 never smokers) who delivered singleton live births at Boston Medical Center. A total of 207 cases were preterm or low-birth-weight infants and 534 were non-low-birth-weight, full-term infants (control).Main Outcome Measure Birth weight, gestation, fetal growth by smoking status and CYP1A1 Mspl (AA vs Aa and aa, where Aa and as were combined because of small numbers of as and similar results), and GSTT1 (present vs absent) genotypes.Results Without consideration of genotype, continuous maternal smoking during pregnancy was associated with a mean reduction of 377 g (SE, 89 g) in birth weight (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.2-3.7). When CYP1A1 genotype was considered, the estimated reduction in birth weight was 252 g (SE, 111 g) for the AA genotype group (n = 75; OR, 1.3; 95% CI, 0.6-2.6); but was 520 g (SE, 124 g) for the Aa/aa genotype group (n=43 for Aa, n=6 for aa; OR, 3.2; 95% CI, 1.6-6.4). When GSTT1 genotype was considered, the estimated reduction in birth weight was 285 g (SE, 99 g) (OR, 1.7; 95% CI, 0.9-3.2) and 642 g (SE, 154 g) (OR, 3.5; 95% Cl, 1.5-8.3) for the present and absent genotype groups, respectively. When both CYP1A1 and GSTT1 genotypes were considered, the,greatest reduction in birth weight was found among smoking mothers with the CYP1A1 Aa/aa and GSTT1 absent genotypes (-1285 g; SE, 234 g; P