Fallopian Tube Correlates of Ovarian Serous Borderline Tumors
Fallopian Tube Correlates of Ovarian Serous Borderline Tumors
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DOI：
10.1097/pas.0b013e318233b0f7
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发表时间：
2011-12-01
影响因子：
5.6
通讯作者：
Crum, Christopher P.
中科院分区：
文献类型：
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作者：
Laury, Anna R.;Ning, Gang;Crum, Christopher P.
卵巢浆液性交界性肿瘤（SBT）被认为起源于卵巢皮质或腹膜表面。输卵管（FT）的发病作用尚不清楚，然而，最近，分泌细胞生长（SCOTs）缺乏PAX 2的表达被描述在良性FT。本研究阐述了（1）SBT的分化特征和（2）SBT患者FT中缺乏PAX 2表达的SCOUT的频率，并将（3）SCOUT形态学和（4）PAX 2表达与SBT进行了比较。SBT和FT上皮共同的纤毛（p73）和分泌（HMFG 2）分化。SBT患者FT横截面的PAX 2-null SCOUT频率为0.28（398例中的110例），而良性前列腺切除术中为0.112，儿科和产后绝育标本中几乎为0（P = < 0.001）。当调整年龄时，差异缩小，但仍显着（P = 0.010）。SCUTs是异质性的，一些显示纤毛分化和乳头状结构。2例FT中的离散多灶性乳头状SCUT与SBT相关。所有SBT均具有不均匀的PAX 2染色，并伴有PAX 2丢失区域。这项研究首次表明，PAX 2-null SCOUT在患有SBT的女性的输卵管中更常见，并且PAX 2表达的缺失发生在大多数SBT中。这些发现将输卵管中的形态和功能基因（PAX 2）改变与SBT联系起来，类似于高级别浆液性癌中的报道。输卵管与浆液性肿瘤的关系有待进一步研究。
Ovarian serous borderline tumors (SBTs) are presumed to originate in the ovarian cortex or peritoneal surface. The pathogenetic role of the fallopian tube (FT) is unclear; however, recently, secretory cell outgrowths (SCOUTs) lacking PAX2 expression were described in benign FTs. This study addressed (1) the differentiation characteristics of SBTs and (2) the frequency of SCOUTs lacking PAX2 expression in the FTs of patients with SBTs and compared (3) SCOUT morphology and (4) PAX2 expression with SBTs. SBTs and FT epithelium shared both ciliated (p73) and secretory (HMFG2) differentiation. PAX2-null SCOUT frequency in FT cross-sections from patients with SBTs was 0.28 (110 of 398) versus 0.112 in benign hysterectomies and nearly 0 in pediatric and postpartum sterilization specimens (P = < 0.001). When adjusted for age, the differences narrowed but remained significant (P = 0.010). SCOUTs were heterogeneous, some displaying ciliated differentiation and papillary architecture. Two cases of discrete multifocal papillary SCOUTs in the FTs were associated with SBTs. All SBTs had heterogeneous PAX2 staining with areas of PAX2 loss. This study shows for the first time that PAX2-null SCOUTs are more common in the oviducts of women with SBTs and that loss of PAX2 expression occurs in most SBTs. These discoveries link both morphologic and functional gene (PAX2) alterations in the oviduct to SBTs, similar to that reported in high-grade serous carcinoma. Further study is warranted to clarify the relationship of the oviduct to serous neoplasia.