MARKERS OF MOUSE MACROPHAGE DEVELOPMENT DETECTED BY MONOCLONAL-ANTIBODIES
MARKERS OF MOUSE MACROPHAGE DEVELOPMENT DETECTED BY MONOCLONAL-ANTIBODIES
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DOI：
10.1016/0022-1759(94)90005-1
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发表时间：
1994-09-14
影响因子：
2.2
通讯作者：
VANEWIJK, W
中科院分区：
文献类型：
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作者：
LEENEN, PJM;DEBRUIJN, MFTR;VANEWIJK, W
在这篇综述中，我们提出并讨论了在小鼠巨噬细胞发育的不同阶段表达的一组抗体定义的标记。我们区分了四类标志物：(1)巨噬细胞前体酸性未成熟巨噬细胞(ER-MP12、ER-MP20、ER-MP54、ER-MP58)：(2)一般成熟巨噬细胞(F4/80、BM8、Mac-1、Mac-2、ER-BMDM1)；(3)巨噬细胞亚群(ER-HR3、ER-MP23、ER-TR9、Forssman抗原、MOMA-1、MOMA-2、MOTS-4、SER-4)和(4)干扰素-γ刺激的巨噬细胞(H-2Ia、LFA-1、ICAM-1、158.2、MBR-2、TM-2、TM-4和TM-5)。应该注意的是，这最后一类中的许多标记物也可以被其他刺激诱导。将标记严格地分成四个独立的组应被视为一个连续体的数字化，从而不可避免地意味着对单核吞噬细胞发育过程中发生的复杂表型变化的简化。然而，目前针对巨噬细胞不同发育阶段标志物的抗体选择构成了表征参与各种生物学过程的小鼠巨噬细胞的重要工具。
In this review, we present and discuss a selected panel of antibody-defined markers expressed during different stages of mouse macrophage development. We distinguish four categories of markers, which are characteristic of: (1) macrophage precursors acid immature macrophages (ER-MP12, ER-MP20, ER-MP54, ER-MP58); (2) mature macrophages in general (F4/80, BM8, Mac-1, Mac-2, ER-BMDM1); (3) macrophage subsets (ER-HR3, ER-MP23, ER-TR9, Forssman antigen, MOMA-1, MOMA-2, Monts-4, SER-4), and (4) IFN-gamma-stimulated macrophages (H-2Ia, LFA-1, ICAM-1, 158.2, MBR-2, TM-2, TM-4, and TM-5). It should be noted that many of the markers in this last category are inducible by other stimuli as well. The rigid classification of markers into four separate groups should be regarded as a digitalization of a continuum, thus inevitably implicating a simplification of the complex phenotypic changes that occur during mononuclear phagocyte development. Nevertheless, the current selection of antibodies against markers for different developmental stages of macrophages constitutes an important tool for characterization of mouse macrophages which participate in various biological processes.