Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection
Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection
复制标题
肠切除后大鼠盲肠和结肠对亚油酸和胆固醇的摄取
作者：
M. T. Molina;V. Ruíz;C. Vázquez;J. Bolufer
研究了大鼠远端小肠切除(DSBR)后盲肠和结肠对亚油酸和胆固醇的摄取。结果表明，手术增加了盲肠和结肠对亚油酸的摄取。补充亚麻酸可抑制盲肠和结肠对亚油酸的摄取。在鱼藤酮和哇巴因存在下进行的实验表明，促进扩散是盲肠和结肠亚油酸吸收的主要机制，至少在低浓度时是这样。手术后盲肠和结肠对胆固醇的摄取增加。研究表明，促进扩散似乎是盲肠和结肠吸收亚油酸的机制，盲肠和结肠上皮细胞的器官生长和运输功能的变化似乎都参与了肠道对肠切除的适应性反应。
Caecal and colonic uptake of both linoleic acid and cholesterol were studied in rats after distal small bowel resection (DSBR). The results showed that the surgical operation increased the caecal and colonic uptake of linoleic acid. Supplementation with linolenic acid inhibited caecal and colonic uptake of linoleic acid. Experiments carried out in the presence of rotenone and ouabain suggest that facilitated diffusion is the predominant mechanism of caecal and colonic linoleic acid absorption, at least at low concentrations. An increase in caecal and colonic uptake of cholesterol was observed after the surgical operation. The study showed that facilitated diffusion seems to be the mechanism of linoleic acid absorption in the caecum and colon, and that both organ growth and changes in transport function of the epithelial cells of caecum and colon appear to be involved in the adaptive response of the bowel to intestinal resection.