RECOVERY FROM UNILATERAL LABYRINTHECTOMY IN RHESUS-MONKEY
RECOVERY FROM UNILATERAL LABYRINTHECTOMY IN RHESUS-MONKEY
复制标题
DOI：
10.1152/jn.1988.59.2.370
复制
发表时间：
1988-02-01
影响因子：
2.5
通讯作者：
ZEE, DS
中科院分区：
文献类型：
--
作者：
FETTER, M;ZEE, DS
1.我们记录了眼球运动在六只恒河猴之前和之后的单侧前庭神经节切除术和量化的静态和动态干扰的前庭眼反射（VOR）的补偿。2.当首次记录后，视网膜切除术（18-20小时后损伤），所有动物都有自发性眼震，平均慢相速度范围为24至54度/秒，在黑暗中测量和0-4度/秒，在光测量。眼球震颤的水平迅速下降，术后第25天，在黑暗中测量的平均值范围为4至22度/秒。慢相的波形是可变的，但在术后第一周，其轨迹通常表现为增加，或先增加后减少，速度。这一发现表明，外周前庭病变可以改变功能的眼运动眼位置积分。3.在黑暗中旋转（30-300度/秒）期间，VOR增益（眼速/头速，校正自发性眼球震颤）从术前的近1.0减少到术后首次测量时的约0.5，除了以高速向病变侧旋转时增益甚至更低。在术后最初几天内，向完整侧旋转时，VOR增益迅速增加，约为0.8。对于朝向损伤侧的旋转，在30-60度/s的刺激下注意到类似的行为，但是在更高的速度下补偿进行得更慢。术后3个月，向完好侧旋转的增益值范围为0.77至1.03，向病变侧旋转的增益值范围为0.61至0.98。较低速度的刺激值较高。4.在未手术耳中用冰水进行热量测试引起眼球震颤，术前最大慢相速度平均值为129度/s，术后3个月为195度/s。损伤侧无热反应。从增加热量反应从完整的耳朵，我们推断相当大的恢复前庭神经元的自发活动的去传入侧。5. VOR的时间常数是术前刺激速度的函数，对于60度/s的刺激，最大平均值为35 s。切除后VOR时间常数在所有速度下都很低（6.0-9.1 s）。随后，仅在3只动物中，椎板切除术后3个月期间VOR时间常数略有增加（2-3 s）。这些结果表明，前庭切除术深刻和持久的损害前庭速度存储机制的行动。（400字处截断摘要）
1. We recorded eye movements in six rhesus monkeys before and after unilateral labyrinthectomy and quantified the compensation for both the static and the dynamic disturbances of the vestibuloocular reflex (VOR). 2. When first recorded after labyrinthectomy (18-20 h postlesion), all animals had a spontaneous nystagmus with mean slow-phase velocities ranging from 24 to 54 degrees/s measured in darkness and 0-4 degrees/s measured in the light. The level of nystagmus diminished quickly, and by postoperative day 25 mean values ranged from 4 to 22 degrees/s, measured in darkness. The waveform of individual slow phases was variable, but in the first postoperative week its trajectory usually showed an increasing, or an increasing then decreasing, velocity. This finding indicates that peripheral vestibular lesions can alter the function of the ocular motor eye-position integrator. 3. The VOR gain (eye velocity/head velocity, corrected for spontaneous nystagmus) during rotations (30-300 degrees/s) in the dark was diminished from nearly 1.0 preoperatively to approximately 0.5 when first measured after labyrinthectomy, except for rotations toward the lesioned side at high speeds for which the gain was even lower. Within the first few postoperative days, for rotations toward the intact side, the VOR gain increased rapidly, to approximately 0.8. For rotations toward the lesioned side similar behavior was noted for stimuli of 30-60 degrees/s, but at higher velocities compensation proceeded more slowly. By 3 mo postoperatively gains had reached values ranging from 0.77 to 1.03 for rotations toward the intact side and from 0.61 to 0.98 for rotations toward the lesioned side. Values were higher for lower-velocity stimuli. 4. Caloric testing with ice water in the unoperated ear elicited nystagmus with a mean value of maximum slow-phase velocity of 129 degrees/s preoperatively and 195 degrees/s 3 mo postoperatively. There was no caloric response on the lesioned side. From the increase in caloric responses from the intact ear we infer considerable restoration of spontaneous activity of vestibular neurons on the deafferented side. 5. The time constant of the VOR was a function of stimulus speed preoperatively with a maximum mean value of 35 s for a 60 degrees/s stimulus. After labyrinthectomy the VOR time constant was low (6.0-9.1 s) at all speeds. Subsequently, in three animals only, there was a small increase (2-3 s) in VOR time constant during the 3-mo period following labyrinthectomy. These results indicate that labyrinthectomy profoundly and persistently impairs the action of the vestibular velocity-storage mechanism.(ABSTRACT TRUNCATED AT 400 WORDS)