The epidemiology of Alzheimer disease in intellectual disability: results and recommendations from an international conference.
The epidemiology of Alzheimer disease in intellectual disability: results and recommendations from an international conference.
复制标题
DOI：
10.1111/j.1365-2788.1997.tb00679.x
复制
发表时间：
2007-02
期刊：
影响因子：
--
通讯作者：
W. Zigman;N. Schupf;M. Haveman;W. Silverman
中科院分区：
文献类型：
--
作者：
W. Zigman;N. Schupf;M. Haveman;W. Silverman
在智力残疾的成年人中，几乎所有40岁以上的唐氏综合征（DS）患者的神经病理学目前被认为与阿尔茨海默病（AD）的诊断一致，而其他没有DS的智力残疾成年人在65岁后表现出阿尔茨海默型神经病理学的患病率增加。本文介绍了在一次智力残疾者老年痴呆症国际会议上形成的一个流行病学工作组讨论的结果，内容涉及：(1)成人智力残疾者临床痴呆的发病率和患病率；(2)成人智障患者AD发生的危险因素；(3)为未来研究成人智障患者的AD提供了极具实用价值的最小数据集。
Among adults with intellectual disability, virtually everyone with Down's syndrome (DS) over the age of 40 years has neuropathology currently viewed to be consistent with a diagnosis of Alzheimer disease (AD), while other adults with intellectual disability without DS display an increased prevalence of Alzheimer-type neuropathology after they reach the age of 65. This paper presents the results of discussions by an epidemiology workgroup, formed at an international conference convened to discuss AD among people with intellectual disability, concerning: (1) the incidence and prevalence of clinical dementia in adults with intellectual disability; (2) risk factors for the development of AD in adults with intellectual disability; and (3) a minimum data set that would be of great utility for future research on AD in adults with intellectual disability.