Rapid and efficient microwave-assisted synthesis of N-carbamoyl-L-amino acids
Rapid and efficient microwave-assisted synthesis of N-carbamoyl-L-amino acids
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DOI：
10.1080/00397910701317068
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Strazzolini, Paolo
中科院分区：
文献类型：
--
作者：
Verardo, Giancarlo;Geatti, Paola;Strazzolini, Paolo
A rapid and efficient method for the synthesis of N-carbamoyl-L-amino acids is reported. The procedure, involving the reaction between urea and alpha-amino acids sodium salts, was performed under microwave conditions using an unmodified domestic microwave oven. A careful study of the operative conditions indicated proline (1d) as the less reactive substrate and phenylglycine (1e) as the more reactive one among all the alpha-amino acids tested. Substitution of urea with potassium cyanate produced a low conversion into the corresponding N-carbamoyl derivative, and a possible explanation of this result is reported.
