Multiple representations in the hippocampus.
Multiple representations in the hippocampus.
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DOI：
10.1002/hipo.450010305
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发表时间：
1991-07-01
期刊：
影响因子：
3.5
通讯作者：
Muller, R U
中科院分区：
文献类型：
--
作者：
Kubie, J L;Muller, R U
位置细胞的发现（O 'Keefe和Dostrovsky，1971）是最强烈地暗示海马体的空间处理作用的发现。在这篇文章中，我们将回顾海马体所代表的空间被“分块”成称为“环境”的片段的证据。这并不是一个新的想法;它是由O 'Keefe和Nadel在The Hippocampus LIS 0 Cognirive Mup（1978）中间接提出的。海马体代表环境这一概念的一个结果是，海马体储存了许多环境表征。在任何给定时间只有一个是活动的。这篇文章的大部分内容旨在说明海马体存储（或访问）多种环境表征的事实的后果。在继续之前，明确我们所说的环境是什么是有用的。我们将环境定义为特定设置的可访问空间以及可用于定向的线索。这一定义与一般的实验策略一致，即当大鼠处于一个实验装置中时，从位置细胞进行记录，而该实验装置本身是在一个有窗帘的封闭空间内。在这样的设置中，相对容易证明位置细胞放电是由封闭物内的装置和其他线索决定的（O 'Keefe和Conway，1978; Olton等人，1978年; Muller和Kubie，1987年）。例如，窗帘内一组受控线索的旋转产生了位置细胞空间放电模式的相等旋转（O 'Keefe和Conway，1978）。因此，位置细胞放电信号大鼠的位置相对于环境的线索，并建议大鼠海马映射当前的环境。如果一个环境是什么映射，会发生什么时，老鼠被放进第二个或第三个环境'！观察到的结果很简单。如果环境足够不同，则将发生“重新映射”（O 'Keefe和Conway，1978; Kubie和Ranck，1984; Muller和Kubie，1987; Thompson和Best，1989; Bostock等人，1991年）。重映射有两个基本特征。首先，海马体对个体环境的表征利用了一个令人惊讶的小的潜在位置细胞子集，即“活跃子集”。根据Thompson和Best（1989），活性亚群的大小约为锥体细胞群的20%。此外，每个环境中使用的子集是
The discovery of place cells (O’Keefe and Dostrovsky, 1971) is the finding that most strongly implicates a spatial processing role for the hippocampus. In this essay we will review evidence that the space represented by the hippocampus is “chunked” into segments called “environments.” This is not a new idea; it was indirectly suggested several times by O’Keefe and Nadel in The Hippocampus LIS 0 Cognirive Mup (1978). A consequence of the notion that the hippocampus represents environments is that the hippocampus stores many environmental representations. only one of which is active at any given time. The bulk of this essay is aimed at stating consequences of the fact that the hippocampus stores (or has access to) multiple environmental representations. Before proceeding, it is useful to make explicit what we mean by an environment. We define an environment as the accessible space of a particular setting together with the cues available for orientation. This definition is consistent with the general experimental strategy of recording from place cells while the rat is in an experimental apparatus that, itself, is within a curtained enclosure.’In such settings, it is relatively easy to demonstrate that place cell firing is determined by the apparatus and other cues within the enclosure (O’Keefe and Conway, 1978; Olton et al., 1978; Muller and Kubie, 1987). For instance, rotations of a set of controlled cues within the curtains produces equal rotations of the spatial firing patterns of place cells (O’Keefe and Conway, 1978). Thus, place cell firing signals the rat’s location with respect to environmental cues and suggests that the rat hippocampus maps the current environment. If an environment is what is mapped, what happens when the rat is put in a second or a third environment ‘! The observed results are quite simple. If the environments are sufficiently different, a “remapping” will occur (O’Keefe and Conway, 1978; Kubie and Ranck, 1984; Muller and Kubie, 1987; Thompson and Best, 1989: Bostock et al., 1991). Remapping has two fundamental features. First, the hippocampal representation of an individual environment makes use of a surprisingly small subset of potential place cells, the “active subset.” The size of the active subset is about 20% of the pyramidal cell population, according to Thompson and Best (1989). Moreover, the subset used in each environment is a