THE DESIGN OF MOLECULAR HOSTS, GUESTS, AND THEIR COMPLEXES
THE DESIGN OF MOLECULAR HOSTS, GUESTS, AND THEIR COMPLEXES
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DOI：
10.1126/science.3283937
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发表时间：
1988-05-06
期刊：
影响因子：
56.9
通讯作者：
CRAM, DJ
中科院分区：
文献类型：
--
作者：
CRAM, DJ
发展了主客体化学的起源、定义、工具和指导原则。栖息，筑巢，和胶囊复合物的例子，通过分子模型和晶体结构的比较。宿主结合的预组织程度是其结合力的核心决定因素。主体和客体中结合位点位置的互补性是复合中结构识别的中心决定因素。实例给出的手性识别络合，部分转酰酶模拟物，caviplexes，和一个合成的分子细胞。
The origins, definitions, tools, and guiding principles of host-guest chemistry are developed. Perching, nesting, and capsular complexes are exemplified through molecular model and crystal structure comparisons. The degree of preorganization of a host for binding is a central determinant of its binding power. Complementarity of binding site placement in host and guest is a central determinant of structural recognition in complexation. Examples are given of chiral recognition in complexation, of partial transacylase mimics, of caviplexes, and of a synthetic molecular cell.