Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy.
Familial occurrence of pulmonary embolism after intravenous, adipose tissue-derived stem cell therapy.
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DOI：
10.3349/ymj.2013.54.5.1293
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发表时间：
2013-09
影响因子：
2.4
通讯作者：
Kim JY
中科院分区：
文献类型：
--
作者：
Jung JW;Kwon M;Choi JC;Shin JW;Park IW;Choi BW;Kim JY
人多能间充质干细胞，特别是人脂肪组织来源的干细胞（hASC）的治疗潜力是有希望的。然而，存在关于输注hASC在人体中的安全性的担忧。最近，我们在多次静脉输注自体hASC治疗的家庭成员中经历了肺栓塞和梗死。一位41岁男性，因胸痛一个月来就诊。胸部CT显示多发性肺动脉栓塞和右肺梗死。血清D-二聚体为0.8 µg/mL（正常; 0-0.5 µg/mL）。他接受了三次静脉自体脂肪组织来源的干细胞治疗颈椎间盘突出症（访视前1个月、2个月和3个月）。他的父母也接受了五次相同的治疗，他们的胸部CT也显示了多发性肺栓塞。这些病例代表静脉注射hASC后的人工肺栓塞和梗死。随访胸部CT显示所有3例患者的病变均自发消退。
The therapeutic potential of human multipotent mesenchymal stromal cells, especially human adipose tissue-derived stem cells (hASC), is promising. However, there are concerns about the safety of infusion of hASC in human. Recently, we have experienced pulmonary embolism and infarct among family members who have taken multiple infusions of intravenous autologous hASC therapy. A 41-year-old man presented with chest pain for one month. Chest CT showed multiple pulmonary artery embolism and infarct at right lung. Serum D-dimer was 0.8 µg/mL (normal; 0-0.5 µg/mL). He had received intravenous autologous adipose tissue-derived stem cell therapy for cervical herniated intervertebral disc three times (one, two, and three months prior to the visit). His parents also received the same therapy five times and their chest CT also showed multiple pulmonary embolism. These cases represent artificial pulmonary embolisms and infarct after IV injection of hASC. Follow-up chest CT showed spontaneous resolution of lesions in all three patients.