Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy
Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy
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DOI：
10.1007/s003800200043
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发表时间：
2002-12-01
影响因子：
1.5
通讯作者：
Shigematsu, Y
中科院分区：
文献类型：
--
作者：
Hara, Y;Hamada, M;Shigematsu, Y
本研究旨在比较贝凡洛尔（一种具有α阻滞和血管舒张活性的β（1）选择性受体阻滞剂）与美托洛尔（一种β（1）选择性受体阻滞剂）治疗特发性扩张型心肌病（DCM）的疗效。 41 名 DCM 患者除接受 DCM 标准治疗外，还接受贝凡洛尔或美托洛尔治疗。他们被分为两组：16 名患者接受贝凡洛尔治疗，25 名患者接受美托洛尔治疗。在治疗前和治疗 6 个月后测量超声心动图参数以及心房和脑钠尿肽（ANP、BNP）。两组治疗后舒张末期和收缩末期左心室尺寸均显着降低，缩短分数显着高于治疗前。两组血浆ANP和BNP水平均显着降低。除收缩压外，所有变量的变化在两组之间均无显着差异。总之，贝凡洛尔对 DCM 患者的心功能和利尿钠肽显示出与美托洛尔平行的有益作用。
This study was designed to compare the efficacy of bevantolol, a beta(1)-selective blocker with alpha-blockade and vasodilating activity, with that of metoprolol, a beta(1)-selective receptor blocker, for the treatment of idiopathic dilated cardiomyopathy (DCM). Forty-one patients with DCM were enrolled to receive either bevantolol or metoprolol in addition to the standard therapy for DCM. They were classified into two groups: 16 patients were treated with bevantolol and 25 were treated with metoprolol. Echocardiographic parameters and atrial and brain natriuretic peptides (ANP, BNP) were measured before treatment and after 6 months of treatment. Left ventricular dimension at end-diastole and end-systole was significantly lower and fractional shortening was significantly higher after treatment than before treatment in both groups. The plasma ANP and BNP levels were significantly decreased in both groups. Changes in all variables, except for systolic blood pressure, showed no significant differences between the two groups. In conclusion, bevantolol showed parallel beneficial effects to those of metoprolol on cardiac function and natriuretic peptides in patients with DCM.