Small RNA guides for de novo DNA methylation in mammalian germ cells
Small RNA guides for de novo DNA methylation in mammalian germ cells
复制标题
DOI：
10.1101/gad.1669408
复制
发表时间：
2008-04-15
影响因子：
10.5
通讯作者：
Bourc'his, Deborah
中科院分区：
文献类型：
--
作者：
Aravin, Alexei A.;Bourc'his, Deborah
生殖系基因组甲基化对哺乳动物配子的身份和完整性至关重要。Kuramochi-Miyagawa及其同事的研究（第908-917页）发表在上一期的《基因与发育》杂志上，该研究将逆转录转座子的DNA甲基化依赖性抑制过程与胎儿男性生殖细胞中发生从头甲基化的pifi相互作用rna （piRNAs）的存在联系起来。
Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (pp. 908-917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.