ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
ShRNA silencing glycogen synthase kinase-3 beta inhibits tumor growth and angiogenesis in pancreatic cancer.
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DOI：
10.1016/j.canlet.2011.10.033
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发表时间：
2012-03
期刊：
影响因子：
9.7
通讯作者：
W. Zhou;Li Wang;S. Gou;Tong-ling Wang;Meng Zhang;Tao Liu;Chun-you Wang
中科院分区：
文献类型：
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作者：
W. Zhou;Li Wang;S. Gou;Tong-ling Wang;Meng Zhang;Tao Liu;Chun-you Wang
Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine protein kinase, plays a vital role in the tumorigenesis of many cancers, but its role in pancreatic cancer remains unknown. In this study, we showed that GSK-3β was aberrantly activated in pancreatic cancer. GSK-3β knockdown resulted in arrested proliferation and increased apoptosis in pancreatic cancer cell lines. Expression of Bcl-2 and vascular endothelial growth factor (VEGF) decreased significantly in a GSK-3β knockdown group. In a xenograft tumor model, GSK-3β knockdown inhibited tumor growth and angiogenesis. Our study showed that GSK-3β may become a promising therapeutic target for human pancreatic cancer.
