Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal axis in the rat
Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal axis in the rat
复制标题
DOI：
10.1530/joe-12-0404
复制
发表时间：
2013-04-01
影响因子：
4
通讯作者：
Mulroney, Susan E.
中科院分区：
文献类型：
--
作者：
Eshkevari, Ladan;Permaul, Eva;Mulroney, Susan E.
电针(EA)用于治疗慢性应激，但其缓解应激的作用机制(S)尚不清楚。下丘脑-垂体-肾上腺轴(HPA)和交感神经系统(SNS)应激激素的相互作用在应激反应中起关键作用。本研究的目的是观察电针胃36穴对慢性冷应激所致大鼠激素水平升高的预防作用。实验动物分为4组，其中3组为冷暴露组，1组为非治疗对照组。在暴露于寒冷之前，两组在冷应激前10天接受电针ST36或Sham-EA治疗。电针ST36组大鼠外周血Hp激素(ACTH和CORT)水平较应激组显著降低(P
Electroacupuncture (EA) is used to treat chronic stress; however, its mechanism(s) of action in allaying stress remains unclear. The interplay of stress hormones of the hypothalamus-pituitary-adrenal axis (HPA) and the sympathetic nervous system (SNS) is critical in the stress response. Our objective was to determine whether EA at acupoint, stomach 36 (EA St(36)) is effective in preventing chronic cold stress-induced increased hormone levels in the rat by examining four groups of animals, three of which were exposed to cold and one of which was a non-treatment control group. Before exposure to the cold, two groups were treated with either EA St36, or Sham-EA, before 10 days of cold stress. The EA St36 animals demonstrated a significant decrease in peripheral HP hormones (ACTH and CORT) compared with stress animals (P