A chronicle of SARS-CoV-2: Part -I-Epidemiology, diagnosis, prognosis, transmission and treatment
A chronicle of SARS-CoV-2: Part -I-Epidemiology, diagnosis, prognosis, transmission and treatment
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DOI：
10.1016/j.scitotenv.2020.139278
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发表时间：
2020-09-10
影响因子：
9.8
通讯作者：
Dhangar, Kiran
中科院分区：
文献类型：
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作者：
Kumar, Manish;Taki, Kaling;Dhangar, Kiran
为了造福公众、社区工作者和科学界，我们特此介绍 SARS-CoV-2 的编年史，它导致了因冠状病毒疾病 (COVID-19) 导致的社会疏远和封锁的前所未见的先例。关于这种危及生命的新型冠状病毒肺炎 (COVID-19) 流行病的信息很少且离散；由于有关该主题的每日出版物数量众多，信息传播日益紧迫。因此，我们对 SARS-CoV-2 和 COVID-19 的各个方面进行了全面综述。我们科学地整理了各种来源的已发表研究、新闻和报告，以理解和总结有关冠状病毒的信息和发现。该审查明确涵盖了 SARS-CoV-2 的基因组和谱系等方面； COVID-19 的流行病学、预后、发病机制、症状和诊断，以便对传播途径以及环境因素对病毒传播的影响的正确信息进行分类，以便深入了解正确管理 COVID-19 的正确战略步骤。我们明确强调了一些有用的信息和事实，例如：i) SARS-CoV-2 的进展与温度、湿度和/或两者之间没有确定的关系，ii) SARS-CoV-2 的潜在机制尚未完全了解，iii) 呼吸道飞沫大小决定飞沫和空气传播，iv) COVID-19 的预后可以通过其对各种身体器官的影响来进行，v) 可以通过限制感染来阻止感染 S 蛋白和 AE2 的结合，vi) 对于 COVID-19，羟氯喹被认为比氯喹更好，vii) 伊维菌素与 Vero-hSLAM 细胞能够在 2 天内将感染减少约 5000 倍，viii) 甲磺酸 Nafamostat 可以抑制 SARS-CoV-2 S 蛋白引发的膜融合。我们还提出了未来的研究观点、挑战和范围。
In order to benefit the public, community workers and scientific community, we hereby present a chronicle of SARS-CoV-2 that leads to the unseen precedent of social distancing and lockdown owing to coronavirus disease (COVID-19). Information on this life-threatening pandemic of COVID-19 is sparse and discrete; and the urgency is such that the dissemination of information is increasing with numerous daily publications on the topic. Therefore, we developed a comprehensive review on various aspects of SARS-CoV-2 and COVID-19. We scientifically compiled published research, news, and reports from various sources to comprehend and summarize the information and findings on Coronaviruses. The review explicitly covers the aspects like genome and pedigree of SARS-CoV-2; epidemiology, prognosis, pathogenesis, symptoms and diagnosis of COVID-19 in order to catalog the right information on transmission route, and influence of environmental factors on virus transmissions, for the robust understanding of right strategical steps for proper COVID-19 management. We have explicitly highlighted several useful information and facts like: i) No established relationship between progression of SARS-CoV-2 with temperature, humidity and/or both, ii) The underlying mechanism of SARS-CoV-2 is not fully understood, iii) Respiratory droplet size determines drop and airborne-based transmission, iv) Prognosis of COVID-19 can be done by its effects on various body organs, v) Infection can be stopped by restricting the binding of S protein and AE2, vi) Hydroxychloroquine is believed to be better than chloroquine for COVID-19, vii) Ivermectin with Vero-hSLAM cells is able to reduce infection by similar to 5000 time within 2 days, and viii) Nafamostat mesylate can inhibit SARS-CoV-2 S protein-initiated membrane fusion. We have also suggested future research perspectives, challenges and scope.