Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth
Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth
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DOI：
10.1016/j.febslet.2007.08.075
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发表时间：
2007-10-02
期刊：
影响因子：
3.5
通讯作者：
Tohyama, Masaya
中科院分区：
文献类型：
--
作者：
Okuda, Hiroaki;Miyata, Shingo;Tohyama, Masaya
果蝇的平面细胞极性（PCP）基因prickle先前已被指示为在早期胚胎阶段原肠胚形成的调节因子之一。然而，刺痛在大脑中的功能作用特别是不知道。我们首先指出，小鼠Prickle1和Prickle2在整个胚胎阶段的大脑中持续表达，并观察到在有丝分裂后的神经元中特异性表达。此外，Prickle1或Prickle2缺失有效地降低了小鼠神经母细胞瘤Neuro2a细胞的神经突生长水平。这些结果表明，小鼠Prickle1和Prickle2可能在脑发育过程中调节阳性神经突的形成。(c)2007年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
The Drosophila planar cell polarity (PCP) gene prickle has been previously indicated as one of the regulators of gastrulation in the early embryonic stage. However, the functional role of prickle in the brain in particular is not known. We first indicated that mouse Prickle1 and Prickle2 are continually expressed in the brain throughout the embryonic stages and are observed to be specifically expressed in the postmitotic neurons. Furthermore, Prickle1 or Prickle2 depletion effectively decreases the neurite outgrowth levels of mouse neuroblastoma Neuro2a cells. These results indicate that mouse Prickle1 and Prickle2 possibly regulate positive neurite formation during brain development. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.