Intravenous olfactory test latency correlates with improvement in post-infectious olfactory dysfunction
Intravenous olfactory test latency correlates with improvement in post-infectious olfactory dysfunction
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DOI：
10.1080/00016489.2017.1325005
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发表时间：
2017-01-01
影响因子：
1.4
通讯作者：
Kondo, Kenji
中科院分区：
文献类型：
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作者：
Horikiri, Kyohei;Kikuta, Shu;Kondo, Kenji
结论：这项队列研究表明，静脉嗅觉测试(IVO)的潜伏期有助于预测感染后嗅觉障碍(PIOD)患者嗅觉改善的时间。目的：确定预测PIOD患者嗅觉改善时间的因素。方法/主要：对1994-2014年间连续出现PIOD患者的所有随访2年的患者进行回顾性分析。用单因素和多因素回归分析人口学/临床因素(年龄、性别、体重指数、是否患有变应性鼻炎、是否接受中药治疗、患者是否依赖中药治疗、是否患有糖尿病、吸烟状况)和嗅觉测试因素(体外测试中的反应/无反应、发病潜伏期和持续时间，以及T&T嗅觉测试中的检测和识别分数)预测嗅觉改善的时间(分别定义为从PIOD开始或嗅觉测试到第一次嗅觉改善的时间)。结果：187例PIOD患者中，对65例患者进行人口学/临床因素的预后分析。没有人预测到嗅觉改善期。在65名患者中，有20名患者在静脉注射试验中没有反应。在其余45例患者中，起病潜伏期(而不是其他嗅觉测试因素)是嗅觉改善时间的显著预测因素(R2=0.24，p=0.003)。
Conclusion: This cohort study showed that onset latency in the intravenous olfactory test (IVO) may help predict when olfaction in patients with post-infectious olfactory dysfunction (PIOD) improves.Objectives: To identify factors that predict the olfactory improvement period in patients with PIOD.Methodology/Principal: All consecutive patients presenting with PIOD in 1994-2014 who were followed up for 2 years were identified retrospectively. The ability of demographic/clinical factors (age, sex, body mass index, presence/absence of allergic rhinitis, treatment/non-treatment with herbal medicines, patient dependence on herbal medicine treatment, presence/absence of diabetes mellitus, and smoking status) and olfactory test factors (response/no response and onset latency and duration in the IVO test, and detection and recognition scores on the T&T olfactory test) to predict the olfactory improvement period (defined respectively as the time from PIOD onset or olfactory testing to the first self-report of olfaction improvement) was analyzed by univariate and multivariate regression.Results: Of the 187 PIOD patients, the prognostic ability of demographic/clinical factors was analyzed in 65. None predicted the olfactory improvement period. Of the 65 patients, 20 did not respond in the IVO test. In the remaining 45 patients, onset latency (but not the other olfactory test factors) was a significant prognosticator of olfactory improvement period (R-2=0.24, p = 0.003).