Early childhood adversity and adolescent depression: the mediating role of continued stress
Early childhood adversity and adolescent depression: the mediating role of continued stress
复制标题
DOI：
10.1017/s0033291708002857
复制
发表时间：
2008-04-01
影响因子：
6.9
通讯作者：
Najman, J.
中科院分区：
文献类型：
--
作者：
Hazel, N. A.;Hammen, C.;Najman, J.
背景虽然童年逆境和后来的抑郁症之间的联系已经提供了各种概念化，大多数没有考虑到早期逆境预测持续压力接近抑郁症发作的可能性。因此，本研究测试了近期压力在早期逆境和晚期抑郁之间的可能中介作用。研究问题进行了检查，在纵向社区样本的705名青年谁是同时评估早期逆境暴露在5岁之前，慢性和偶发性压力在15岁之前，15岁和15至20岁之间的严重抑郁症。15岁时的总青年压力负担介导了15至20岁之间早期逆境对抑郁症的影响，并且没有观察到的关系被15岁之前抑郁症的发作所缓和。这些发现表明，持续的压力暴露接近抑郁症发作在很大程度上解释了早期逆境和青春期后期抑郁症之间的联系。因此，干预措施应侧重于破坏整个童年和青少年时期压力状况的连续性。未来的研究，早期经验和抑郁症之间的联系的神经生物学和心理社会机制，应探讨早期经验的影响是否是独立的持续逆境接近抑郁症发作。
Background. While various conceptualizations of the link between childhood adversity and later depression have been offered, most have not accounted for the possibility that early adversity predicts continuing stress proximal to depression onset. Thus, the present study tested the possible mediating role of recent stress in the association between early adversity and depression in late adolescence.Method. Study questions were examined in a longitudinal community sample of 705 youth who were contemporaneously assessed for early adversity exposure prior to age 5 years, chronic and episodic stress at age 15 years, and major depression prior to age 15 years and between 15 and 20 years.Results. Total youth stress burden at age 15 years mediated the effect of early adversity on depression between ages 15 and 20 years, and none of the observed relationships were moderated by onset of depression prior to age 15 years.Conclusions. These findings suggest that continued stress exposure proximal to depression onset largely accounts for the association between early adversity and depression in late adolescence. Intervention should thus focus oil disrupting the continuity of stressful conditions across childhood and adolescence. Future studies of the neurobiological and psychosocial mechanisms of the link between early experiences and depression should explore whether the effects of early experiences are independent of continuing adversity proximal to depressive onset.