Does ovarian autoimmunity play a role in the pathophysiology of premature ovarian insufficiency?
Does ovarian autoimmunity play a role in the pathophysiology of premature ovarian insufficiency?
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DOI：
10.4103/0976-7800.66986
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发表时间：
2010-01
影响因子：
1.1
通讯作者：
Khole V
中科院分区：
文献类型：
--
作者：
Khole V
卵巢早衰（POF）是导致闭经和不孕的重要原因。然而，有些妇女可能自发排卵和怀孕。因此，原发性卵巢功能不全（POI）是首选术语。POF / POI的病因是多因素的。自身免疫是加速卵泡破坏的重要机制。本文综述了自身免疫在POI病理生理学中的作用。针对多种卵巢抗原的抗体已被提议作为卵巢自身免疫的标志物。然而，一直缺乏临床证明的敏感性和特异性的血清试验，以确认自身免疫参与POI。该综述详细介绍了最近开发的抗卵巢抗体（AOA）的特异性测试，该测试能够识别卵巢中不同的分子抗原靶点。AOA特异性检测的应用揭示了在患者接受IVF技术之前筛查自身免疫的必要性。
Premature Ovarian Failure (POF) is an important cause of amenorrhoea and infertility. However some women may spontaneously ovulate and conceive. Primary ovarian insufficiency (POI) is thus the preferred term. POF / POI is multifactorial in etiology. Autoimmunity is an important mechanism for accelerated destruction of ovarian follicles. The present review focuses on the role of autoimmunity in the pathophysiology of POI. Antibodies to multiple ovarian antigens have been proposed as markers of ovarian autoimmunity. However, there has been lack of clinically proven sensitive and specific serum tests to confirm autoimmune involvement in POI. The review details recently developed specific test for antiovarian antibodies (AOA) that has enabeled identification of different molecular antigenic targets in the ovary. The application of this specific test for AOA has brought to light the need for screening for autoimmunity prior to patients undergoing IVF technique.