Racial differences in sex hormone levels in women approaching the transition to menopause
Racial differences in sex hormone levels in women approaching the transition to menopause
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DOI：
10.1016/s0015-0282(00)01723-4
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发表时间：
2001-02-01
影响因子：
6.7
通讯作者：
Grisso, JA
中科院分区：
文献类型：
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作者：
Manson, JM;Sammel, MD;Grisso, JA
目的：评价随时间推移激素水平再现性的种族差异（雌二醇、DHEAS、FSH和睾酮），同时调整先前在研究人群中确定为相关的协变量。设计：纵向队列研究。设置：以社区为基础的样本中的健康晚期育龄妇女。患者：通过随机数字拨号确定的非裔美国人和高加索妇女。干预：在月经周期的早期卵泡期测量激素水平，在9个月内测量4次。一个多变量线性混合模型估计了种族、入组年龄、初潮年龄、怀孕次数、当前吸烟、饮酒、体重指数（BMI）、腰臀比（WHR）和月经周期长度对激素水平的影响。主要结果指标：卵泡血浆雌二醇、FSH、DHEAS和睾酮水平。随着年龄的增长，非裔美国人而不是高加索妇女的雌二醇和DHEAS水平显着降低。非裔美国人而非白人女性随着BMI的增加，雌二醇水平显著降低，DHEAS水平显著升高。没有种族差异的再现性激素measurements.Conclusions（S）：有种族差异的激素水平与年龄和体重指数的协会在生育年龄后期的妇女。需要进一步的研究来复制这些发现并确定这些激素与更年期症状的关系。（C）2001年由美国生殖医学会。
Objective: Evaluate racial differences in reproducibility of hormone levels over time (estradiol, DHEAS, FSH, and testosterone) while adjusting for covariates previously identified as relevant in the study population.Design: Longitudinal cohort study.Setting: Healthy, late-reproductive-age women in a community-based sample.Patient(s): African American and Caucasian women identified by random digit dialing.Intervention(s): Hormone levels measured in the early follicular phase of the menstrual cycle four times over 9 months. A multivariate, linear mixed model estimated effects on hormone levels of race, age at enrollment, age at menarche, number of pregnancies, current smoking, alcohol consumption, body mass index (BMI), waist/hip ratio (WHR), and menstrual cycle length.Main Outcome Measure(s): Follicular plasma levels of estradiol, FSH, DHEAS, and testosterone.Result(s): African American but not Caucasian women had significantly lower levels of estradiol and DHEAS with increasing age. African American but not Caucasian women had significantly decreased levels of estradiol and significantly increased levels of DHEAS with increasing BMI. No racial differences in reproducibility of hormone measures were found.Conclusion(s): There are racial differences in associations of hormone levels with age and BMI in late reproductive age women. Further study is needed to replicate these findings and to determine the relationships of these hormonal associations with menopausal symptoms. (C)2001 by American Society for Reproductive Medicine.