THE INCREASE OF ENDOTHELIAL PROGENITOR CELLS IN THE PERIPHERAL BLOOD: A NEW PARAMETER FOR DETECTING ONSET AND SEVERITY OF SEPSIS
THE INCREASE OF ENDOTHELIAL PROGENITOR CELLS IN THE PERIPHERAL BLOOD: A NEW PARAMETER FOR DETECTING ONSET AND SEVERITY OF SEPSIS
复制标题
DOI：
10.1177/039463200802100324
复制
发表时间：
2008-07-01
影响因子：
3.5
通讯作者：
Amedei, A.
中科院分区：
文献类型：
--
作者：
Becchi, C.;Pillozzi, S.;Amedei, A.
脓毒症是一种以非特异性炎症反应为特征的临床综合征，其内皮功能和结构发生了深刻的变化。最近的证据表明，血管的维持、修复和血管生成部分是由从骨髓（BM）募集内皮祖细胞（EPCs）介导的。在这项研究中，我们感兴趣的是，是否EPCs在脓毒症过程中越来越多地动员，如果这种动员与脓毒症的严重程度。我们的流式细胞术数据表明，在CD 34+细胞门中，脓毒症患者血液中的EPCs数量增加了4倍（45 +/- 4.5%，p < 0.05）。
Sepsis is a clinical syndrome characterized by non-specific inflammatory response with evidence of profound changes in the function and structure of endothelium. Recent evidence suggests that vascular maintenance, repair and angiogenesis are in part mediated by recruitment from bone marrow (BM) of endothelial progenitor cells (EPCs). In this study we were interested in whether EPCs are increasingly mobilized during sepsis and if this mobilization is associated with sepsis severity. Our flow cytometry data demonstrate that in the CD34+ cell gate the number of EPCs in the blood of patients with sepsis had a four-fold increase (45 +/- 4.5% p