A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index
A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index
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DOI：
10.1111/j.1365-2052.2006.01547.x
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发表时间：
2007-02-01
期刊：
影响因子：
2.4
通讯作者：
Whitehead, C. C.
中科院分区：
文献类型：
--
作者：
Dunn, I. C.;Fleming, R. H.;Whitehead, C. C.
骨质疏松症是由母鸡产蛋期间结构骨逐渐丧失引起的，与骨质断裂的易感性增加有关。为了研究骨强度的遗传基础，从商业纯种白来航种群中根据骨指数不同选择的母鸡品系产生了 F-2 杂交。使用 32 个 F-1 家族中 372 个 F-2 个体的表型数据绘制了影响骨指数和指数组成特征（胫跗骨和肱骨强度以及龙骨放射照相密度）的数量性状基因座 (QTL)。使用科内回归分析，分析了 27 个连锁群中 136 个微卫星标记的基因型，覆盖了大约 80% 的基因组，以了解其与表型的关联。骨指数及胫跗骨、肱骨断裂强度组成性状在1号染色体上存在1个显着QTL。胫骨断裂强度的加性效应代表性状标准偏差的 34% 和性状表型方差的 7.6%。这些家禽骨质量 QTL 与商业种群直接相关。
Osteoporosis, resulting from progressive loss of structural bone during the period of egg-laying in hens, is associated with an increased susceptibility to bone breakage. To study the genetic basis of bone strength, an F-2 cross was produced from lines of hens that had been divergently selected for bone index from a commercial pedigreed White Leghorn population. Quantitative trait loci (QTL) affecting the bone index and component traits of the index (tibiotarsal and humeral strength and keel radiographic density) were mapped using phenotypic data from 372 F-2 individuals in 32 F-1 families. Genotypes for 136 microsatellite markers in 27 linkage groups covering similar to 80% of the genome were analysed for association with phenotypes using within-family regression analyses. There was one significant QTL on chromosome 1 for bone index and the component traits of tibiotarsal and humeral breaking strength. Additive effects for tibiotarsal breaking strength represented 34% of the trait standard deviation and 7.6% of the phenotypic variance of the trait. These QTL for bone quality in poultry are directly relevant to commercial populations.